Clinical manifestations of hyperkalemia

Written by Zhao Xin Lan
Endocrinology
Updated on October 29, 2024
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The clinical manifestations of hyperkalemia are not specific. Early symptoms often include numbness in the limbs, sensory abnormalities, extreme fatigue, and muscle pain. In severe cases, there can be difficulties in swallowing, speaking, and breathing, paralysis of the limbs, and tendon reflexes may disappear. The central nervous system may show signs of restlessness, fainting, and confusion. Some may experience a slow heart rate, ventricular fibrillation, and in the most severe cases, it can lead to cardiac arrest. Other symptoms may include nausea, vomiting, diarrhea, and other gastrointestinal symptoms.

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Written by Wei Shi Liang
Intensive Care Unit
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The difference between hyperkalemia and hypokalemia.

Hypokalemia refers to a serum potassium concentration lower than 3.5mmol/L, and its clinical manifestations are diverse. The most life-threatening symptoms involve the cardiac conduction system and the neuromuscular system. Mild hypokalemia shows on an electrocardiogram as flattened T waves and the appearance of U waves, while severe hypokalemia can lead to fatal arrhythmias, such as torsades de pointes and ventricular fibrillation. In terms of the neuromuscular system, the most prominent symptom of hypokalemia is the loss of tone in smooth muscles and flaccid paralysis in skeletal muscles, which, when involving respiratory muscles, can lead to respiratory failure. Hyperkalemia, on the other hand, refers to a serum potassium concentration exceeding 5.5mmol/L, mainly presenting clinical symptoms in cardiac and neuromuscular conduction. Severe cases can cause bradycardia, atrioventricular conduction block, and even sinus arrest. Mild hyperkalemia, with levels between 5.5 to 6.0mmol/L, shows on an electrocardiogram as peaked T waves. As hyperkalemia continues to increase, it can lead to lengthening of the PR interval or disappearance of the P wave, QRS widening, and eventually cardiac arrest. Regarding the neuromuscular system, the clinical manifestations of hyperkalemia are very similar to those of hypokalemia, including weakness and paralysis of skeletal and smooth muscles.

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Written by Wei Shi Liang
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Common Causes of Hyperkalemia

Hyperkalemia is when the serum potassium concentration exceeds 5.5 millimoles per liter. Common causes include excessive potassium intake and large doses of potassium salts, which can lead to hyperkalemia, as well as the use of stored blood. Another cause is reduced potassium excretion; in patients with renal insufficiency, reduced urine output or anuria leads to decreased renal potassium excretion. If potassium supplementation is inappropriate at this time, or if potassium-sparing diuretics are used, severe hyperkalemia can occur. Another scenario is the leakage of intracellular potassium during respiratory and metabolic acidosis, where sodium ion exchange occurs in cells, hydrogen ions enter the cells, and potassium ions leak out to the extracellular space, which can lead to increased blood potassium. These are the common causes of hyperkalemia.

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Why should calcium be supplemented for hyperkalemia?

When high potassium levels trigger ventricular automaticity, it is recommended to administer calcium to counteract its cardiotoxicity. This is because during hyperkalemia, the excitability of the myocardium significantly increases. Calcium ions do not affect the distribution of potassium inside and outside the cells, but they can stabilize the excitability of the heart. Therefore, even if a patient's blood calcium level is normal, calcium should be injected immediately when there is severe arrhythmia. Calcium ions only temporarily counteract the toxicity of potassium to the heart and do not reduce the concentration of potassium in the blood. Thus, they can only serve as a short-term emergency medication. (Medication should be used under the guidance of a doctor.)

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Written by Chen Li Ping
Endocrinology
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Hyperkalemia

Typically, when serum potassium exceeds 5.5 mmol/L, it is referred to as hyperkalemia. However, an increase in serum potassium does not necessarily reflect an overall increase in body potassium; serum potassium can also rise when there is a deficiency of total body potassium. Therefore, in clinical practice, serum potassium is evaluated in conjunction with an electrocardiogram and medical history to determine if a patient has hyperkalemia. Hyperkalemia is an important emergency in internal medicine and can often lead to sudden cardiac arrest. It should be identified and prevented early.

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Written by Zhao Xin Lan
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Causes of hyperkalemia

The causes of hyperkalemia may include: First, excessive intake, such as consuming too much high-potassium food, medications with high potassium content, including some traditional Chinese medicines, potassium penicillin, stored blood, and excessive potassium supplementation. Second, it could be due to decreased potassium excretion by the kidneys. When renal insufficiency, acute or chronic renal failure occurs, it is often accompanied by severe hyperkalemia. Third, there is also decreased potassium secretion by renal tubules. When there is a deficiency of corticosteroids, there can be degenerative, asymptomatic hyperkalemia. Hyperkalemia can also occur when renal tubules are insensitive to aldosterone. Fourth, medications that reduce potassium excretion, such as the use of potassium-sparing diuretics, angiotensin-converting enzyme inhibitors, other nonsteroidal anti-inflammatory drugs, cyclosporine, etc., can also cause hyperkalemia. Fifth, the shift of potassium from inside the cells to the extracellular fluid, which can be caused by tissue damage, hypoxia, or the use of certain medications, leading to hyperkalemia.