How to treat advanced gastric cancer?

Written by Liu Liang
Oncology
Updated on September 03, 2024
00:00
00:00

The treatment for advanced gastric cancer is primarily chemotherapy, especially for patients with peritoneal or retroperitoneal lymph node metastasis, or distant organ metastasis such as to the liver or lungs. The treatment primarily involves chemotherapy, specifically choosing either multi-drug intravenous combination chemotherapy or oral monotherapy, such as oral chemotherapy with tegafur capsules, or broad-spectrum targeted therapies like apatinib that inhibit angiogenesis. The choice of treatment depends on a comprehensive consideration of the patient's overall condition. If the patient's general condition is particularly poor and the chemotherapy risk is assessed to be high, then the approach for such advanced-stage patients is primarily the best symptomatic supportive treatment to alleviate suffering as much as possible. Therefore, the treatment plan must be determined based on a comprehensive consideration of the specific situation.

Other Voices

doctor image
home-news-image
Written by Liu Liang
Oncology
1min 11sec home-news-image

Can stomach cancer be cured?

Whether gastric cancer can be cured depends on the stage of the cancer, as well as the patient's own physical condition. For example, early-stage gastric cancer patients, who are diagnosed as early-stage through examinations such as endoscopic ultrasonography and enhanced CT of the chest and abdomen, and assessed by surgeons as suitable for curative surgery, are primarily treated with curative surgery. The prognosis for these early-stage gastric cancer patients is generally good, with a relatively high five-year survival rate. Post-operation, based on the pathological findings, it is decided whether postoperative adjuvant radiotherapy and chemotherapy are necessary. There is hope for curing patients in these early stages through these treatment methods. However, if a patient is found to have advanced-stage gastric cancer, for example with metastases to distant organs like the liver and lungs, the cancer is not completely curable. The purpose of treatment in such cases is to alleviate the patient's pain and extend their survival, but it can’t achieve a curative effect.

doctor image
home-news-image
Written by Liu Liang
Oncology
50sec home-news-image

How to check for gastric cancer?

When clinical symptoms such as nausea, vomiting, gastric distension or upper abdominal pain, acid reflux, or hematemesis, as well as melena occur, it is necessary to consider the possibility of gastric cancer and seek timely medical attention. Completing a gastroscopy and obtaining a biopsy under gastroscopy are essential. If cancer cells are found, this is the most important diagnostic method for confirming gastric cancer. After the diagnosis of gastric cancer, further examinations like endoscopic ultrasound and CT scans of the chest and abdomen are required to assess the approximate stage of the patient and to decide the subsequent treatment plan.

doctor image
home-news-image
Written by Liu Liang
Oncology
1min 26sec home-news-image

How is stomach cancer treated?

The treatment for gastric cancer now includes surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy, among others. The specific treatment plan is formulated based on various factors such as the staging of the cancer, the patient's overall condition, and the presence of any underlying diseases, which are all taken into consideration before deciding on a treatment plan. For patients in the early stages who are generally in good condition, surgical resection can be evaluated and is primarily curative. Post-operative treatment decisions, such as whether to pursue adjuvant radiotherapy or chemotherapy, depend on the pathology results and the presence of high-risk factors for recurrence. For patients in advanced stages who are found to have distant metastases upon diagnosis, treatment is primarily chemotherapy. Additionally, there are broad-spectrum targeted therapies against angiogenesis, such as apatinib, which are suitable for patients with advanced gastric cancer or those who do not respond well to chemotherapy, serving as a secondary or tertiary line of treatment. These are some of the treatment methods for gastric cancer. It is crucial that the use of any medication is conducted under the guidance of a doctor.

doctor image
home-news-image
Written by Liu Liang
Oncology
49sec home-news-image

What is early-stage gastric cancer?

In the early stages of gastric cancer, the tumor is confined to the mucosa or submucosa, regardless of whether there is regional lymph node metastasis or not; this is still classified as early-stage gastric cancer. The treatment for early-stage gastric cancer primarily involves curative surgery, which is the first option unless the patient is of advanced age or has severe underlying diseases that prevent tolerance of surgical treatment. Excluding these cases, surgical treatment is generally the first choice. Furthermore, the outcome of surgical treatment for patients with early-stage gastric cancer is generally quite positive, with a five-year survival rate typically exceeding 80%.

doctor image
home-news-image
Written by Liu Liang
Oncology
1min 12sec home-news-image

What are the symptoms of gastric cancer?

The symptoms of gastric cancer patients are generally common gastrointestinal symptoms such as nausea, vomiting, acid reflux, and discomfort and bloating in the upper abdomen, especially aggravated after eating. As the condition progresses, symptoms may include vomiting blood or black stools. When the cancer invades surrounding organs, clinical symptoms such as abdominal effusion, abdominal distension, and pain may occur. If the tumor is located near the pylorus and causes pyloric obstruction, symptoms of pyloric obstruction will appear, such as gastric retention, acid reflux, and vomiting of overnight food. Additionally, if the tumor bleeds, it may cause severe vomiting of blood. Therefore, different stages of the disease present different symptoms. If gastric cancer progresses to the late stage with metastasis to distant organs, clinical manifestations corresponding to the sites of metastasis will also appear.