How to treat advanced gastric cancer?

Written by Liu Liang
Oncology
Updated on September 03, 2024
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The treatment for advanced gastric cancer is primarily chemotherapy, especially for patients with peritoneal or retroperitoneal lymph node metastasis, or distant organ metastasis such as to the liver or lungs. The treatment primarily involves chemotherapy, specifically choosing either multi-drug intravenous combination chemotherapy or oral monotherapy, such as oral chemotherapy with tegafur capsules, or broad-spectrum targeted therapies like apatinib that inhibit angiogenesis. The choice of treatment depends on a comprehensive consideration of the patient's overall condition. If the patient's general condition is particularly poor and the chemotherapy risk is assessed to be high, then the approach for such advanced-stage patients is primarily the best symptomatic supportive treatment to alleviate suffering as much as possible. Therefore, the treatment plan must be determined based on a comprehensive consideration of the specific situation.

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Written by Liu Liang
Oncology
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What are the symptoms of stomach cancer?

Symptoms of gastric cancer, especially in the early stages, generally include nausea, vomiting, loss of appetite, discomfort or bloating in the upper abdomen, pain, and acid reflux as some of the gastrointestinal symptoms, as well as vomiting blood and black stools. Black stools are tar-like stools, and their occurrence indicates bleeding in the upper gastrointestinal tract. Additionally, if the tumor causes pyloric obstruction, the patient will vomit food eaten the night before, be completely unable to eat, and experience a significant weight loss. In even more advanced stages, gastric cancer patients may develop a cachectic state.

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Written by Liu Liang
Oncology
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What are the symptoms of gastric cancer?

The symptoms of gastric cancer patients are generally common gastrointestinal symptoms such as nausea, vomiting, acid reflux, and discomfort and bloating in the upper abdomen, especially aggravated after eating. As the condition progresses, symptoms may include vomiting blood or black stools. When the cancer invades surrounding organs, clinical symptoms such as abdominal effusion, abdominal distension, and pain may occur. If the tumor is located near the pylorus and causes pyloric obstruction, symptoms of pyloric obstruction will appear, such as gastric retention, acid reflux, and vomiting of overnight food. Additionally, if the tumor bleeds, it may cause severe vomiting of blood. Therefore, different stages of the disease present different symptoms. If gastric cancer progresses to the late stage with metastasis to distant organs, clinical manifestations corresponding to the sites of metastasis will also appear.

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Written by Liu Liang
Oncology
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What can stomach cancer patients eat?

For patients with gastric cancer, there are no specific dietary taboos, except for avoiding foods that are too spicy or greasy, such as fried foods and barbecued items that are difficult to digest. Additionally, it is advisable to avoid carbonated and very cold foods that may irritate the stomach. The dietary approach should focus on eating smaller, more frequent meals that are easy to digest and bland. However, it is also important to ensure a balanced diet that includes both meat and vegetables to ensure adequate nutrition for the patient.

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Written by Liu Liang
Oncology
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Late-stage symptoms of gastric cancer

The common late-stage symptoms of gastric cancer patients include nausea, vomiting, and even a complete inability to eat. There are also symptoms related to the digestive tract such as pain in the upper abdomen and acid reflux, as well as upper gastrointestinal bleeding, such as vomiting blood and melena which are signs of lower gastrointestinal bleeding. Late-stage gastric cancer patients may also experience organ metastasis, leading to corresponding symptoms. For example, metastasis of gastric cancer to the liver can cause abdominal pain and ascites due to hepatic metastatic tumors. Clinical manifestations caused by such metastatic tumors also include metastasis to retroperitoneal lymph nodes in the abdominal cavity, a common site of spread for gastric cancer. Patients may even show symptoms of intestinal obstruction, such as abdominal pain, bloating, nausea, vomiting, inability to pass stool, or even absence of flatus, which are indicators of intestinal obstruction. Consequently, patients might experience weight loss and deteriorate into a cachectic state, marked by poor nutrition and significant weight loss, which are characteristic symptoms of late-stage patients.

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Written by Ren Zheng Xin
Gastroenterology
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Is gastric cancer contagious?

Gastric cancer is a malignant tumor occurring in the epithelial cells of the gastric mucosa. It is non-contagious. Currently, the incidence of gastric cancer is relatively high, primarily due to Helicobacter pylori infection, adverse environmental factors, and dietary irritants. Genetic factors also play a significant role, with 10% of gastric cancer patients having a family history. Those with a family history of gastric cancer have an incidence rate that is 2 to 3 times higher than the general population. Additionally, precancerous lesions can also induce gastric cancer, such as intestinal metaplasia, gastric polyps, residual gastritis, and gastric ulcers. Typical symptoms include indigestion, anemia, lack of appetite, aversion to food, and fatigue. Currently, gastroscopy combined with mucosal biopsy is the most reliable diagnostic method.