How to rule out lymphoma in children

Written by Zhang Xiao Le
Hematology
Updated on February 01, 2025
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Lymphoma is a malignant tumor originating from the lymphatic system. The main clinical manifestation is painless lymph node enlargement, which can occur in superficial lymph nodes such as in the neck, armpits, or groin, as well as deeper lymph nodes in the mediastinum or abdominal cavity. In pediatric patients with lymphoma, a significant number also present with abdominal pain, intestinal obstruction, or intussusception, which often indicates intestinal lymphoma. If children exhibit lymph node enlargement or deep lymph node enlargement is discovered through imaging studies, it is necessary to perform a puncture or biopsy and conduct a pathological examination to further confirm whether it is lymphoma.

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Causes of Malignant Lymphoma

Currently, the causes of lymphoma are not clear. It may be related to genetic mutations, infections, pathogens, or other viruses. Additionally, exposure to radiation or chemical drugs, and its association with autoimmune diseases, are also relevant factors. Clinically, there are specific types of lymphoma, such as mucosa-associated lymphoma related to the stomach lining, which is notably associated with Helicobacter pylori infections. Another type is related to infection with the Epstein-Barr virus.

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How long can lymphoma last?

In clinical practice, lymphomas are classified into Hodgkin's lymphoma and non-Hodgkin's lymphoma. Non-Hodgkin's lymphoma is a relatively common type of tumor in China and has the highest incidence among lymphomas. However, it is further divided into dozens of subtypes, each with distinct clinical symptoms. Aggressive lymphomas can be cured, while indolent lymphomas can be managed with the tumor remaining. Thus, the question of how long one can live with lymphoma cannot be generalized; it depends on the type and stage of the disease, and many can be cured completely.

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Can people with lymphoma eat beef?

The diet for lymphoma patients isn't particularly special; it’s just like the diet of healthy individuals, with no need for specific dietary restrictions. Moreover, there aren't any prohibitions related to "hot-natured" foods as mentioned in traditional Chinese medicine. From a Western medicine perspective, the focus is simply on enhancing the patient's nutrition. This can be achieved by eating smaller, more frequent meals, and ensuring a balanced diet with a good mix of meat and vegetables. There are no special dietary taboos; all foods are permissible, provided one avoids junk food. Therefore, foods like beef and lamb are perfectly acceptable.

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How is lymphoma diagnosed?

Most lymphoma patients initially present with painless swelling of superficial lymph nodes. The first examination typically includes an ultrasound of these superficial lymph nodes. If the ultrasound suggests a high probability of malignancy, a lymph node excision biopsy can be performed. A lymph node excision biopsy and subsequent pathological confirmation is the gold standard for diagnosing lymphoma. Furthermore, it is common for lymphoma patients to undergo PET-CT scans, which are used to determine the stage at initial diagnosis and to assess the effectiveness of treatment after therapy.

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Early symptoms of lymphoma

The early symptoms of lymphoma patients are primarily due to its predilection for lymph nodes, with the majority of cases initially presenting with swollen lymph nodes in the neck or collarbone area. These lymph nodes usually enlarge progressively without pain, which is the most common early clinical symptom. However, some specific types of lymphoma, such as nasal NKT lymphoma, present with localized symptoms like nasal congestion, nosebleeds, or a runny nose. There are also lymphomas originating in the stomach, part of the digestive tract, whose symptoms include upper abdominal pain, nausea, or vomiting. Furthermore, some lymphomas originate in the skin, manifesting as skin nodules. Therefore, depending on the site of occurrence, the symptoms can vary, but the enlargement of superficial lymph nodes remains the primary clinical manifestation in most cases.