How is lymphoma diagnosed?

Written by Liu Liang
Oncology
Updated on May 21, 2025
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Most lymphoma patients initially present with painless swelling of superficial lymph nodes. The first examination typically includes an ultrasound of these superficial lymph nodes. If the ultrasound suggests a high probability of malignancy, a lymph node excision biopsy can be performed. A lymph node excision biopsy and subsequent pathological confirmation is the gold standard for diagnosing lymphoma. Furthermore, it is common for lymphoma patients to undergo PET-CT scans, which are used to determine the stage at initial diagnosis and to assess the effectiveness of treatment after therapy.

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Written by Liu Liang
Oncology
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Is lymphoma the same as lymphatic cancer?

Lymphoma refers to a type of malignant tumor that originates in lymph nodes or extranodal tissues or organs. The cancer we usually talk about refers to malignant tumors originating from epithelial tissues, which we call cancer, such as lung cancer, liver cancer, etc. Therefore, lymphoma is actually what non-medical professionals commonly refer to as lymphatic cancer. It is simply called lymphoma instead of cancer because it originates in lymph nodes or extranodal tissues or organs, and therefore, it is termed malignant lymphoma, which in layman's terms is lymphatic cancer.

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Written by Peng Li Bo
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Hodgkin's lymphoma symptoms and signs

Actually, whether it is Hodgkin's lymphoma or non-Hodgkin's lymphoma, the symptoms and signs are quite similar. In terms of symptoms, because lymphoma mainly occurs as a lesion in the lymph nodes, it is characterized by superficial, localized enlargement of the lymph nodes. Common locations include the neck, then the armpits, and the groin—areas where lymph nodes are more prevalent. It manifests as a local swelling; simply put, you might feel a lump or a tumor on your neck, which is the most common symptom. Additionally, there are other systemic symptoms including fever, weight loss, night sweats, and itchy skin, among others. As for the physical signs, it mainly refers to palpable superficial lymph node enlargement upon examination.

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Written by Zhou Zi Hua
Oncology
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Typical symptoms of lymphoma

Typical symptoms of lymphoma include night sweats, fever, and weight loss. This fever often occurs in the afternoon, characterized as a cyclical fever that lasts for several days with irregular patterns. There are fever-free intervals ranging from a few days to several weeks, almost a nonspecific symptom but not commonly seen. Fever, night sweats, and unexplained weight loss of more than 10% within six months, or even emaciation, are considered B symptoms and are associated with a poor prognosis. In addition, skin itching is also not uncommon in late-stage patients.

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Written by Wu Xia
Oncology
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Is lymphoma contagious?

Current research has not found lymphoma to have a very clear genetic predisposition or familial clustering. This is entirely different from familial breast cancer and colon cancer. Although there are many causes of lymphoma, and it is likely related to certain bacterial and viral infections, the mechanism of tumor occurrence is very complex. Infection is only one of the external factors, and currently, there is no evidence that lymphoma has tendencies for contagion or outbreaks. Therefore, as a relative of a lymphoma patient, the risk of developing lymphoma is not significantly higher than that of the general population, so there is no need for excessive worry.

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Written by Liu Liang
Oncology
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What are the symptoms of lymphoma?

The symptoms of lymphoma predominantly start with painless enlargement of superficial lymph nodes, most commonly in areas such as the neck, supraclavicular lymph nodes, armpits, or groin. Additionally, patients with nasal NKT lymphoma might experience nasal congestion, nosebleeds, and rhinorrhea. Lymphomas occurring in the stomach, for example, present symptoms like nausea, vomiting, and even rectal bleeding which are related to the gastrointestinal tract. Therefore, symptoms can vary depending on the location of the lymphoma. Some patients may also experience enlargement of the liver and spleen. In advanced stages of lymphoma, bone marrow involvement is possible, along with common B symptoms including sweating, fever, or weight loss, which are also clinical manifestations seen in lymphoma patients.