In the early stages of uremia, although the condition is not as severe as in full-blown uremia, the patient will still experience many uncomfortable symptoms. For example, after getting up in the morning, the patient may notice swelling in the eyelids on both sides, feel nauseous and have a significant decrease in appetite. They may also feel fatigued and tired after physical activity. Additionally, changes in the volume of urine occur, such as an increase in the frequency of nighttime urination to three to five times. Patients may also experience varying degrees of dizziness, headaches, and gradually increasing blood pressure that is difficult to control. Other symptoms include itchy skin and muscle soreness, among other clinical signs. Therefore, timely treatment in the early stages of uremia is necessary to slow the rapid progression of chronic kidney disease to the uremic stage.