The so-called uremia refers to patients whose kidney function has been lost by more than 90%, and the vast majority of kidney tissue has been destroyed. Although the condition of these patients is very serious, they do not experience pain symptoms. In patients with uremia, the kidney tissue has hardened, and in most of the causes leading to uremia, pain is not induced. Even though the kidneys have severe problems, there are no nerves in the kidneys to sense pain, as there are no sensory nerves, so the kidneys do not feel pain. Causes that can lead to uremia include diabetes, hypertension, chronic nephritis, urinary system stones, tumors, and more. Painful conditions are mainly caused by urinary system stones, while other causes generally do not entail pain.