Does uremia cause blood in urine?

Written by Zhou Qi
Nephrology
Updated on April 25, 2025
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Patients with uremia may experience hematuria, but not all patients will do so. Uremia refers to a condition where over 90% of the patient's kidney tissue has been damaged. Due to the destruction of kidney tissue, when blood passes through the kidneys, it is indeed possible that red blood cells will leak from the glomeruli into the urine. Therefore, patients with uremia may exhibit signs of hematuria, especially those caused by primary chronic glomerulonephritis. If the uremia is caused by tumors or kidney stones leading to urinary obstruction, this situation can cause bleeding in the ureters or bladder, also resulting in hematuria. However, most patients with uremia have a very low chance of experiencing hematuria because the vast majority of their kidney tissue has been destroyed, even up to 100%, leaving no urine production, and thus no blood in the urine. If an anuric patient exhibits hematuria, the possibility of stones, tumors, or urinary tract infections should be considered.

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Written by Guan Hai Fang
Urology
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Is uremia cancer?

Uremia is not cancer. Chronic kidney failure refers to the presence of various kidney diseases that lead to a progressive and irreversible decline in kidney function, culminating in a series of symptoms and metabolic disorders that form a clinical syndrome, commonly known as chronic kidney failure. The end stage of chronic kidney failure is what is often referred to as uremia. Uremia is not a separate disease, but a clinical syndrome common to various late-stage kidney diseases. It is a symptom consisting of a series of clinical manifestations that occur when chronic kidney failure enters its terminal stage. Typically, this includes disturbances in water and electrolyte acid-base metabolism, with metabolic acidosis and water-electrolyte imbalance being the most common.

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Written by Zhou Qi
Nephrology
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What tests are involved in checking for uremia?

Uremia refers to the final stage of chronic renal failure, also known as end-stage kidney disease. Therefore, the first step in examining a patient with uremia is to check renal function. The patient's blood creatinine level must reach a certain level to diagnose uremia. Secondly, it is necessary to examine the urinary system through color Doppler ultrasound, and to conduct blood tests for routine blood indicators, electrolytes, parathyroid hormone, etc. The color Doppler ultrasound shows a reduction in kidney size, which provides evidence for the diagnosis of uremia. Patients with uremia often also suffer from various complications, including anemia, electrolyte disorders, hyperparathyroidism, and so on. Therefore, such patients also need to undergo examinations for routine blood parameters, electrolytes, and parathyroid hormone levels, among other indicators.

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Written by Zhou Qi
Nephrology
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The precursors of uremia

The so-called uremia refers to the end result of chronic kidney disease causing long-term damage to the kidneys in patients. Patients with uremia often have long-standing conditions, as it takes time to progress from mild kidney failure to uremia. Before the onset of uremia, patients may experience symptoms related to kidney failure, such as swelling of the limbs and face, reduced urine output, proteinuria which leads to foamy urine, and visible blood in the urine due to hematuria. Patients are also prone to developing high blood pressure. These symptoms can be precursors to uremia, although other diseases can also cause similar symptoms.

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Written by Li Liu Sheng
Nephrology
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Causes of Uremia

Uremia is a syndrome caused by the progressive development of various chronic kidney diseases, eventually leading to renal failure in patients, where the kidneys are unable to promptly eliminate excess water, various electrolytes, and toxins from the body. There are many causes of uremia; chronic nephritis, diabetic nephropathy, and hypertensive nephropathy are the most common causes. Other causes include chronic tubulointerstitial nephritis, chronic pyelonephritis, chronic obstructive nephropathy, toxic nephropathy, hereditary nephritis, renal vascular diseases, and lupus nephritis. Once uremia occurs, the preferred treatment is dialysis therapy, which can be either hemodialysis or peritoneal dialysis. Only after dialysis treatment can the life of a patient with uremia be prolonged.

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Written by Zhou Qi
Nephrology
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How do you get uremia?

Uremia is actually a state of disease, not an independent disease. It refers to the condition where, due to certain reasons, a patient has long-term chronic damage to the kidneys, leading to the destruction of kidney tissue. When about 90% of the kidney tissue is damaged, a large amount of metabolic waste accumulates inside the body because it cannot be excreted. There may also be retention of water and electrolyte and acid-base imbalances. This condition is referred to as uremia. Diseases that can damage kidney tissue to such a severe extent commonly include diabetes, hypertension, chronic nephritis, systemic lupus erythematosus, and various forms of cancer in the elderly, including multiple myeloma. Obstructive factors in the urinary system can also cause this outcome, such as urinary system stones, tumor prostate hyperplasia, leading to urinary tract obstruction, and so on.