Uremia is actually a state of disease, not an independent disease. It refers to the condition where, due to certain reasons, a patient has long-term chronic damage to the kidneys, leading to the destruction of kidney tissue. When about 90% of the kidney tissue is damaged, a large amount of metabolic waste accumulates inside the body because it cannot be excreted. There may also be retention of water and electrolyte and acid-base imbalances. This condition is referred to as uremia. Diseases that can damage kidney tissue to such a severe extent commonly include diabetes, hypertension, chronic nephritis, systemic lupus erythematosus, and various forms of cancer in the elderly, including multiple myeloma. Obstructive factors in the urinary system can also cause this outcome, such as urinary system stones, tumor prostate hyperplasia, leading to urinary tract obstruction, and so on.