Patients with liver failure are prone to catching colds due to their weakened immune systems. Additionally, when patients with liver failure catch a cold, the fever and overall inflammatory response can lead to further deterioration of liver function. Cold treatment for such patients should be timely. Cold medications, including fever reducers and other drugs, are metabolized through the liver, and thus can have significant effects on it. Therefore, if patients with liver failure exhibit symptoms of a cold, they must seek medical attention promptly and manage their condition under the guidance of a professional doctor, avoiding self-medication or enduring without treatment.