Can ovarian cancer be inherited?

Written by Wu Xia
Oncology
Updated on March 25, 2025
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Ovarian cancer, like most tumors, has genetic factors involved in its etiology, but it is not a genetic disease. Only five to ten percent of ovarian cancer patients have a genetic background. More than ninety percent of ovarian cancer cases are sporadic, meaning that if a mother has ovarian cancer, it does not directly inherit to her daughter. However, individuals with a family history of ovarian cancer have a significantly higher risk of developing the disease compared to the general population, especially those who carry mutations in the BRCA1 and BRCA2 genes. These gene mutations can be inherited from parents, so individuals carrying these mutations have a significantly higher risk of developing ovarian cancer than the healthy population.

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Does ovarian cancer hyperthermic intraperitoneal chemotherapy work?

Patients with ovarian cancer are prone to peritoneal metastasis, so many patients develop ascites during the discovery of the disease or its progression. A large amount of ascites is a common concurrent symptom in patients with ovarian cancer. For patients with significant ascites like this, hyperthermic intraperitoneal chemotherapy (HIPEC) can be performed, which involves infusing chemotherapy drugs into the abdominal cavity and then combining it with thermotherapy. This treatment generally has a decent effect, especially in controlling the spread of cancer cells in the peritoneum and managing ascites.

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Is there still hope for ovarian cancer recurrence?

Most ovarian malignant tumors, which are ovarian cancers, are relatively sensitive to chemotherapy. Therefore, in many cases, the treatment of ovarian cancer is a combination of surgery and chemotherapy. Even if ovarian cancer recurs, there are still many treatment options available, with chemotherapy being the most commonly used method. Many patients can still benefit from chemotherapy.

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How is ovarian cancer diagnosed?

Ovarian cancer is discovered through transvaginal ultrasound of the adnexa uteri revealing ovarian tumors, or through imaging studies such as abdominal CT scans or MRIs showing ovarian tumors, combined with tumor markers, particularly the ovarian epithelial cancer tumor marker CA125, which will be significantly elevated. Generally, with these findings, ovarian cancer can typically be clinically diagnosed. Confirmation, however, requires pathological diagnosis, which involves obtaining a biopsy of the tumor. This can be done through a puncture biopsy or through pathological examination after surgical excision to confirm ovarian cancer. Additionally, some patients with ovarian cancer present with substantial ascites at the time of discovery. If cancer cells are found in the abdominal fluid, combined with a significant increase in CA125 and imaging studies showing ovarian tumors, ovarian cancer can also be diagnosed.

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Location of abdominal pain in ovarian cancer

Ovarian cancer in patients manifests as tumors in either both ovaries or one ovary. Therefore, the abdominal pain they experience is lower abdominal pain, not bloating or sudden, noticeable increase in abdominal size. Additionally, the primary pathway for the metastasis of ovarian cancer is through implantation, allowing widespread metastatic implants in the pelvic and abdominal cavities. There is also local spread of the tumor to the uterus, fallopian tubes, and surrounding pelvic tissues. Thus, the location of abdominal pain in ovarian cancer is in the lower abdomen, specifically pain and bloating in the pelvic area.

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Early treatment methods for ovarian cancer

The treatment methods for early-stage ovarian cancer should first and foremost include a clear diagnosis and staging. If the staging indicates an early stage, then surgical treatment can be applied. There are many surgical options available, such as cytoreductive surgery, interval debulking surgery, second-look laparotomy, and direct tumor cell reduction surgery. After the surgery, adjuvant chemotherapy can be administered for treatment.