Crohn's disease is a chronic nonspecific inflammatory disease that can occur throughout the digestive tract, presenting with mucosal ulcers in a longitudinal and phased distribution. Crohn's disease can flare up in any part of the digestive tract, and currently, there are no highly effective medications to treat it, and the disease can relapse throughout a person's life. There are many supplements available on the market today, and most of them are composed of traditional Chinese medicines, animal proteins, and other substances. Some specific foreign proteins can directly or indirectly activate immune cells, thus exacerbating the immune response. This can potentially worsen the symptoms of the disease, leading to more severe mucosal damage and an overall aggravation of the condition. Therefore, it is not advisable for individuals with Crohn's disease to consume these supplements indiscriminately. It is best to maintain a good diet and lifestyle habits instead.