Why is whooping cough milder during the day and worse at night?

Written by Zeng Hai Jiang
Pediatrics
Updated on February 26, 2025
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Whooping cough is an acute respiratory infectious disease caused by Bordetella pertussis infection, commonly seen in children. The main symptoms are paroxysmal spasmodic coughing, a crowing inspiratory noise, with coughing occurring both during the day and at night, more significantly at night. The main reasons are as follows: first, the dry indoor air causes irritation. Second, during the night, the mucus secreted by the bronchial mucosa cannot be expelled from the body, which stimulates the bronchial nerves and triggers worsening cough symptoms. Coughing can also cause redness of the face and ears, runny nose, nausea, and vomiting.

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Written by Li Jian Wu
Pulmonology
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What is the pertussis vaccine?

The pertussis vaccine we currently administer is a combination vaccine that primarily includes diphtheria, pertussis (whooping cough), and tetanus, commonly referred to as the DTP vaccine. It is generally administered for the first time when a baby is three months old, the second dose at four months of age, and the third dose at five months. A booster vaccine is given again when the child is one and a half to two years old to produce antibodies that can effectively prevent pertussis, a respiratory infectious disease. It is important to detect early, vaccinate in a timely manner, and prevent early.

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Written by Zeng Hai Jiang
Pediatrics
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Can a routine blood test detect whooping cough?

Whooping cough is an acute respiratory infectious disease caused by Bordetella pertussis infection, commonly seen in children. The main symptoms are paroxysmal spasmodic coughing and a crowing inspiratory whoop. The disease has a long course and may be complicated by pneumonia, neurological diseases, and others. The diagnosis of the disease mainly relies on the cultivation of Bordetella pertussis, detection of Bordetella pertussis DNA, and testing for pertussis toxin antibodies. In this disease, the routine blood test will also show a significant increase in the white blood cell count, lymphocyte count, and white blood cell differential.

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Written by Li Jian Wu
Pulmonology
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Where to treat whooping cough?

Pertussis, a respiratory infectious disease, is recommended to be checked and treated at local formal medical institutions. Once diagnosed, the main principle is to kill the Corynebacterium diphtheriae and choose sensitive antibiotics, such as macrolide antibiotics like erythromycin, azithromycin, or clarithromycin. Additionally, symptomatic treatment should be provided, including oxygen therapy for breathing difficulties, using medications to relieve bronchial smooth muscle spasms, thinning mucus, and alleviating uncomfortable symptoms such as coughing. It is also important to drink plenty of water, rest, and maintain good hygiene.

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Written by Li Jian Wu
Pulmonology
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Is nebulization useful for pertussis?

Nebulized inhalation for localized treatment of pertussis can be quite effective. It helps alleviate bronchial smooth muscle spasms and is used for spasmodic coughs, effectively easing cough symptoms as a symptomatic treatment measure. However, it is also necessary to target the infectious pathogens with oral or intravenous macrolide antibiotics for anti-inflammatory treatment. Drinking plenty of water, maintaining suitable indoor temperature and humidity, and having confidence in overcoming the disease are important. Although the course of the disease may be long, complete recovery is possible through proper treatment, so there is no need for excessive worry.

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Written by Tong Peng
Pediatrics
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The difference between pertussis and allergic cough

Pertussis (whooping cough) and allergic cough are different. Firstly, pertussis is an acute respiratory infectious disease caused by Bordetella pertussis. Its symptoms include paroxysmal and frequent coughing, sometimes accompanied by a deep, crowing, inspiratory whoop sound. If not treated promptly, the condition can last for several months, which is why it is called whooping cough. Due to its high contagiosity and epidemic history, if infants contract pertussis, their condition can worsen, making them prone to complications like severe pneumonia or heart failure. However, allergic cough is a non-infectious condition primarily caused by hypersensitivity of the airways, easily triggered by various external allergens, leading to irritating dry coughs, but not worsening to lower respiratory tract infections. In daily life, by avoiding environmental allergens and using treatments such as nebulization and oral antiallergic medications, management is possible.