Can a routine blood test detect whooping cough?

Written by Zeng Hai Jiang
Pediatrics
Updated on April 17, 2025
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Whooping cough is an acute respiratory infectious disease caused by Bordetella pertussis infection, commonly seen in children. The main symptoms are paroxysmal spasmodic coughing and a crowing inspiratory whoop. The disease has a long course and may be complicated by pneumonia, neurological diseases, and others. The diagnosis of the disease mainly relies on the cultivation of Bordetella pertussis, detection of Bordetella pertussis DNA, and testing for pertussis toxin antibodies. In this disease, the routine blood test will also show a significant increase in the white blood cell count, lymphocyte count, and white blood cell differential.

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Written by Li Jian Wu
Pulmonology
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Is the lymphocyte count high in whooping cough?

Pertussis, a disease caused by a bacterial infection, leads to an increase in lymphocytes beyond normal levels during the acute phase. If secondary infections occur, the relative lymphocyte count may decrease. The examination of these white blood cells is only an auxiliary test; culturing the pathogen or using fluorescent antibody staining are also viable methods that can definitively diagnose a pertussis infection. This condition can cause paroxysmal, spasm-like coughing, and some may exhibit a barking cough. Once diagnosed, medication should be selected according to the treatment course, with regular follow-ups.

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Written by Li Jian Wu
Pulmonology
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How is whooping cough treated?

Pertussis, also known as whooping cough, is an infectious respiratory disease caused by the infection of Bordetella pertussis or Bordetella parapertussis. Clinically, it is characterized by episodes of sudden, rapid coughing, a bark-like cough, and an inspiratory "crowing" sound. It is also advisable to check the sputum culture to confirm the cause of the disease. In terms of treatment, in addition to symptomatic treatment, macrolide antibiotics should be selected and administered for at least about half a month. Options include intravenous drips of erythromycin injection or azithromycin injection.

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Written by Li Jian Wu
Pulmonology
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Whooping cough vaccine at what age?

The pertussis vaccine is generally administered within the first year of age. Under normal circumstances, children should be taken to hospitals or public health prevention stations for vaccination according to the course of treatment. The first dose starts at the third month after birth, followed by the second dose at four months and the third dose at five months old. A booster can be administered when the baby is two years old. The DTP vaccine used in clinics mainly consists of three components: pertussis, diphtheria, and tetanus.

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Written by Li Jian Wu
Pulmonology
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How long does it take to recover from pertussis syndrome?

This disease is called whooping cough mainly because the disease itself has a long course, which led to its name. If not treated in time, some patients may take two to three months to recover. If detected and treated early, generally complete recovery is possible within about 10-20 days. The main symptoms are paroxysmal, spasmodic coughing, some may also exhibit a barking cough, or a crowing inspiration sound, among other typical manifestations.

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Written by Tong Peng
Pediatrics
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The difference between pertussis and allergic cough

Pertussis (whooping cough) and allergic cough are different. Firstly, pertussis is an acute respiratory infectious disease caused by Bordetella pertussis. Its symptoms include paroxysmal and frequent coughing, sometimes accompanied by a deep, crowing, inspiratory whoop sound. If not treated promptly, the condition can last for several months, which is why it is called whooping cough. Due to its high contagiosity and epidemic history, if infants contract pertussis, their condition can worsen, making them prone to complications like severe pneumonia or heart failure. However, allergic cough is a non-infectious condition primarily caused by hypersensitivity of the airways, easily triggered by various external allergens, leading to irritating dry coughs, but not worsening to lower respiratory tract infections. In daily life, by avoiding environmental allergens and using treatments such as nebulization and oral antiallergic medications, management is possible.