Is chemotherapy effective for late-stage rectal cancer?

Written by Yu Xu Chao
Colorectal Surgery
Updated on March 08, 2025
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Late-stage rectal cancer is primarily due to the metastasis and proliferation of cancer cells. At this stage, surgery alone cannot completely eliminate cancer cells, so chemotherapy is necessary. Chemotherapy has certain effects clinically, especially in patients who are sensitive to chemotherapy drugs, where the effects are more pronounced. This can control the spread of cancer cells in multiple locations and can, to some extent, improve patient survival rates. For patients, it is important to maintain good health, enhance their immune system, consume foods rich in high-quality proteins, and engage in appropriate exercise. Moreover, maintaining a positive mindset is beneficial for extending life. Additionally, patients can integrate traditional Chinese medicine and acupuncture as complementary therapies, which can also potentially improve postoperative survival rates.

Other Voices

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Written by Chen Tian Jing
Colorectal Surgery
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Is anal pain and rectal bleeding indicative of rectal cancer?

Pain in the anal area, accompanied by blood in the stool, does not necessarily indicate rectal cancer. There are many causes of pain and bloody stools, which require identification and diagnosis through the color of the bloody stools, digital rectal examination, and colonoscopy. Common causes of bright red bloody stools or pain are mainly due to hemorrhoids and anal fissures. During the onset of rectal cancer, early stages generally do not involve pain in the anal area. It is mainly characterized by changes in bowel habits, or dark red blood in the stool in the middle to late stages. The tumor may grow larger, causing difficulty in defecation, and may even induce systemic symptoms such as weight loss, anemia, and intestinal obstruction.

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Written by Zhang Peng
General Surgery
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Is rectal cancer hereditary?

This answer is also possible, as one of the causes of any cancer includes the possibility of genetics. However, this possibility is generally small and not everyone is likely to have it. It also depends on the incidence of disease within the entire family. If one is in a high-risk category due to certain genetic factors, then it is crucial to have regular and thorough follow-up checks. Some people might even try treatments specifically targeting genetically inherited colorectal cancer.

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Written by Si Li Li
Gastroenterology
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How to rule out the possibility of rectal cancer

Common symptoms of rectal cancer include abdominal pain, changes in stool characteristics, and rectal bleeding. These symptoms could suggest the possibility of rectal cancer. An initial examination can be conducted via a digital rectal exam to preliminarily exclude rectal cancer. If a mass is felt during the digital rectal exam, a high suspicion of rectal cancer should be maintained. Additionally, a colonoscopy can be performed for a definitive diagnosis. If a mass on the rectal mucosa is observed during the colonoscopy, a biopsy can be conducted for histopathological examination to determine the nature of the mass. Generally, if the surface of the mass is uneven, brittle, and bleeds easily, the likelihood of malignancy is high while a smooth surface suggests a greater possibility of benignity.

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Written by Yu Xu Chao
Colorectal Surgery
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How to differentiate rectal cancer from hemorrhoids

Rectal cancer is a malignant lesion, with clinical symptoms mainly causing an increase in the frequency of bowel movements, changes in stool characteristics such as grooved stools or stools with mucus and pus and blood. Severe patients may experience abdominal pain, weight loss, anemia, and other accompanying symptoms. Generally, low-lying rectal cancer can be seen during a digital rectal examination or with an anoscope. If the cancer is located higher up, an electronic colonoscopy is needed to see the cauliflower-like mass. Hemorrhoids, on the other hand, are benign lesions often caused by improper diet or poor bowel habits, leading to pathological hypertrophy and descent of the anal cushions. They are mostly characterized by intermittent painless rectal bleeding with bright red blood, along with a feeling of heaviness and a foreign body sensation in the anus.

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Written by Liu Liang
Oncology
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Rectal cancer stage III

Rectal cancer staging is based on the TNM system. "T" refers to the primary tumor, and its stage depends on which layer of the bowel wall the tumor has invaded. "N" is based on whether there are lymph node metastases and the number of lymph nodes involved. "M" indicates whether there are metastases to distant organs. Staging is determined according to the TNM situation, where Stage I is the earliest and Stage IV is the latest. Stage III indicates lymph node metastasis without distant organ metastases, such as to the liver or lungs. In such cases, irrespective of whether T is T1 to T4, if there is lymph node involvement without distant organ metastasis, it is staged as Stage III.