Neonatal hemolytic disease refers to alloimmune hemolysis caused by maternal-fetal blood type incompatibility, commonly seen in life with A, B, O blood type mismatches, and Rh blood type mismatch is less common. Once neonatal hemolytic disease is diagnosed, aggressive treatment must be pursued. Initially, phototherapy treatment is recommended, commonly referred to as blue light therapy. Additionally, medication therapy for the child is necessary, frequently involving albumin and intravenous immunoglobulin, along with the use of sodium bicarbonate to correct acidosis. If the aforementioned treatments do not yield satisfactory results, blood exchange treatment should be considered for the child. This mainly involves removing free antibodies and sensitized red blood cells from the blood, thereby alleviating hemolysis and ultimately achieving therapeutic goals. (Please use medication under the guidance of a doctor.)