How to effectively treat advanced liver cancer?

Written by Yan Chun
Oncology
Updated on April 14, 2025
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In the late stages of liver cancer, due to the spread of lesions, it is very easy to cause the failure of multiple organs such as the liver, heart, and kidneys, ultimately endangering the patient's life. Therefore, effective treatment methods must be adopted to delay the progression of the disease as much as possible. Currently, effective treatment methods include radiotherapy, chemotherapy, targeted therapy, immunotherapy, traditional Chinese medicine, and some physical therapies. Commonly used clinical treatments include radiofrequency ablation and microwave ablation. Radiotherapy is also a local treatment method, while targeted therapy and chemotherapy immunotherapy are systemic comprehensive treatments. Currently, the effects of targeted therapy for liver cancer are satisfactory, but the effects of chemotherapy and immunotherapy are poor. Most patients need these treatments combined to exert their effective anti-tumor treatment functions.

Other Voices

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Written by Yan Chun
Oncology
1min 18sec home-news-image

Do early-stage liver cancer patients experience fatigue?

Patients with early-stage liver cancer generally do not exhibit symptoms of fatigue, which are more commonly seen in patients with mid to late-stage liver cancer. The clinical symptoms of early-stage liver cancer are generally not typical, with a minority of patients experiencing reduced appetite and discomfort or mild pain in the liver area. Furthermore, early-stage liver cancer is often discovered during physical examinations or incidentally. Fatigue in liver cancer patients is mostly due to hypoalbuminemia, moderate to severe anemia, or toxic side effects caused by certain anticancer treatments. Hypoalbuminemia occurs because the growth of liver cancer consumes a large amount of protein, and liver dysfunction leads to insufficient synthesis of both protein and glycogen, resulting in malnutrition in patients. After experiencing weight loss, patients often show signs of fatigue. The pathological changes in liver cancer can lead to moderate to severe anemia, which, in turn, significantly contributes to fatigue. Additionally, some medications used in treating liver cancer can cause fatigue due to their toxic side effects.

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Written by Sun Ming Yue
Medical Oncology
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Symptoms of late-stage liver cancer deterioration

If liver cancer reaches an advanced stage, many symptoms will appear. For example, there will be pain in the liver area due to the tumor's growth pulling on the liver capsule, causing persistent swelling in the upper right part or stomach pain. If the tumor invades the pectoral muscles, it may cause referred pain in the right shoulder or back. Some patients may experience an enlarged liver due to the increased size of the tumor, which feels painful when pressed. Additionally, the increase and pressure from the tumor can obstruct bile excretion, leading to jaundice, and symptoms of cirrhosis may also appear. In general, the main symptoms of advanced liver cancer include fever, fatigue, loss of appetite, and weight loss. If the condition worsens, metastatic symptoms may occur; lung metastasis can cause the patient to cough and expel phlegm, and bone metastasis can cause localized pain and lumps.

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Written by Peng Li Bo
Oncology
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Is primary liver cancer hereditary?

Primary liver cancer is usually not hereditary, but the reason why it tends to appear in families in China is mainly due to the widespread infection of hepatitis B virus, which then leads to a significant correlation with hepatic cirrhosis caused by hepatitis B. It is well known that the hepatitis B virus is contagious and can easily be transmitted within families and from mother to child. Therefore, it is not uncommon to see several cases of liver cancer within the same family, indicating a familial aggregation. Another factor is related to dietary habits, for example, the infection of aflatoxin, which is mainly found in moldy peanuts. If the dietary habits within a family are similar, then, of course, the likelihood of occurrence is certainly higher.

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Written by Liu Liang
Oncology
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What to do if vomiting occurs in liver cancer?

Liver cancer is divided into two main pathological types, the first being hepatocellular carcinoma, which is the most common, and the other being cholangiocellular carcinoma. Clinically, vomiting is also a common symptom of liver cancer. For symptomatic treatment, we can provide gastric protection and administer antiemetic drugs such as stomach comfort, but these are only symptomatic treatments and do not cure the root cause. The key is still to treat the liver cancer itself, as the symptoms will only alleviate once the cancer is under control. For advanced hepatocellular carcinoma, targeted therapies like sorafenib are available. If it is cholangiocellular carcinoma, and symptoms like vomiting and jaundice appear, which may be obstructive symptoms, then a surgical procedure in hepato-biliary surgery to drain the bile can be performed, which can also alleviate the symptoms of vomiting. (Medications should be used under the guidance of a doctor.)

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Written by Yan Chun
Oncology
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Can a cystic lesion in the liver be liver cancer?

Clinically, cystic lesions in the liver are mostly not liver cancer lesions, because liver cancer is a malignant tumor occurring in the liver. Clinically, on imaging, it is mainly manifested as occupying lesions in the liver, appearing as multiple hepatic nodules fused into a mass, or as a huge single nodular lesion. These lesions generally appear as solid lesions. When the tumor is large, ischemic necrosis can occur due to insufficient blood supply to the central area, resulting in cystic changes in the central region of the solid lesion. Therefore, some patients with large liver cancer may have cystic and solid lesions on imaging, but in most cases, liver cancer lesions are solid.