Liver cancer can potentially cause back pain for several reasons: First, the tumor from liver cancer may directly metastasize to locations such as the lumbar vertebrae, resulting in significant and persistent back pain. Second, liver cancer can metastasize to the kidneys via the bloodstream, which clinically can also manifest as back pain and symptoms of blood in the urine. Third, liver cancer can cause kidney function impairment, which likewise can lead to symptoms of back pain. Fourth, patients with liver cancer may experience back pain due to urinary tract infections, which can appear particularly when the infection is severe and the patient's immune system is compromised.