Liver cancer itself does not cause itchy skin, but itchy skin can appear in advanced liver cancer patients due to some complications. Firstly, when liver cancer encroaches on the hepatic portal area, it can invade or compress the biliary system, causing obstruction of the biliary system and increased bilirubin in the blood, which leads to generalized itching. When liver cancer patients also have fungal or parasitic infections of the skin, itching can also occur. Additionally, when liver cancer patients undergo chemotherapy, targeted molecular therapy, or other systemic anti-tumor treatments, they may experience generalized itching due to allergies to medications. In some cases where the allergic reactions are severe, symptoms such as a drop in blood pressure and other manifestations of anaphylactic shock can occur, necessitating prompt treatment.