Should the gallbladder be removed in the early stage of liver cancer?

Written by Yan Chun
Oncology
Updated on March 18, 2025
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Whether early-stage liver cancer patients need to have their gallbladder removed depends on the location of the tumor. For liver cancers located close to the gallbladder, gallbladder removal is generally necessary. For liver cancer lesions that are farther from the gallbladder, it is usually sufficient to only remove the liver tumor, or to perform a resection of the local liver segment or sub-segment. Additionally, for early-stage liver cancer patients to undergo surgery, certain conditions must be met: the tumor must be five centimeters or smaller, there should be no cancerous thrombus in the main trunk of the portal vein, the liver cancer tumor should not involve the semi-dry or full-dry circumstances, and the liver function should be compensatory. Under these conditions, an effort should be made to perform liver tumor resection. Generally, cancers located in the left lobe of the liver require local resection, either of a liver segment or sub-segment, and sometimes resection of the liver lobe may be performed. Tumors located in the right lobe of the liver or the hepatic portal area require local tumor resection.

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Written by Yan Chun
Oncology
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Does early-stage liver cancer cause pain when pressed?

In the early stages of liver cancer, patients generally do not experience pain when pressing on the liver area. Pain in the liver area or a sensation of liver pain typically occurs in the middle or late stages of liver cancer and is a common manifestation. The main reasons for the pain are that the liver cancer lesions are large, causing an increase in liver volume, which leads to a tense pain in the liver capsule. Additionally, the invasion of liver cancer into the liver cells and surrounding tissues can cause pain. Another cause of pain may be abnormal hormone secretion triggered by the lesions, which then stimulates the pain perception centers, resulting in pain. For patients with early-stage liver cancer, the tumors are generally small and usually do not cause noticeable clinical symptoms. In many cases, patients may exhibit non-specific symptoms such as indigestion and mild fatigue. In contrast, patients with middle to late-stage liver cancer often exhibit more clinical manifestations due to the progression of the disease.

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Written by Sun Wei
Surgical Oncology
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The difference between primary liver cancer and secondary liver cancer.

Primary liver cancer generally refers to tumors whose cancer cells originate from the liver itself or from the intrahepatic bile ducts. Secondary liver cancer usually refers to cancer that has metastasized to the liver from other parts of the body, which is the main difference between the two. Additionally, primary liver cancer might progress rapidly, potentially resulting in a short survival time, especially in cases of large, inoperable tumors, where most survival times range from half a year to about a year. In contrast, secondary liver cancer might have a longer survival time, and initial symptoms are generally milder. Also, tumor markers like alpha-fetoprotein (AFP) tend to be higher in primary liver cancer, whereas in secondary liver cancer, this marker may be normal.

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Written by Sun Wei
Surgical Oncology
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Is primary liver cancer contagious?

Primary liver cancer refers to malignant tumors that occur in the liver and are not metastasized from other parts of the body. Such liver cancer itself is not contagious. However, if liver cancer patients have other infectious diseases, transmission may be possible. Most primary liver cancers are related to liver cirrhosis following hepatitis, with hepatitis B being the most common. If accompanied by hepatitis B, it can be contagious, but it usually doesn't spread through regular daily contact. The main transmission routes for hepatitis B are through blood, mother-to-child transmission, and sexual transmission. This means that as long as the patient's blood does not injure someone else, contagion is generally unlikely, so there is no need for excessive worry.

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Medical Oncology
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Late-stage liver cancer vomiting is what symptom?

Patients with advanced liver cancer have no signs before vomiting. If patients with advanced liver cancer experience vomiting, it is often accompanied by other symptoms. For example, some patients may experience diarrhea and body wasting due to loss of appetite, and the nature of the vomiting can vary. Some may vomit food, while others may vomit blood. If the vomit contains blood, it is urgent to consult a doctor promptly for targeted prevention and treatment.

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Written by Peng Li Bo
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Is primary liver cancer hereditary?

Primary liver cancer is usually not hereditary, but the reason why it tends to appear in families in China is mainly due to the widespread infection of hepatitis B virus, which then leads to a significant correlation with hepatic cirrhosis caused by hepatitis B. It is well known that the hepatitis B virus is contagious and can easily be transmitted within families and from mother to child. Therefore, it is not uncommon to see several cases of liver cancer within the same family, indicating a familial aggregation. Another factor is related to dietary habits, for example, the infection of aflatoxin, which is mainly found in moldy peanuts. If the dietary habits within a family are similar, then, of course, the likelihood of occurrence is certainly higher.