Primary liver cancer generally refers to tumors whose cancer cells originate from the liver itself or from the intrahepatic bile ducts. Secondary liver cancer usually refers to cancer that has metastasized to the liver from other parts of the body, which is the main difference between the two. Additionally, primary liver cancer might progress rapidly, potentially resulting in a short survival time, especially in cases of large, inoperable tumors, where most survival times range from half a year to about a year. In contrast, secondary liver cancer might have a longer survival time, and initial symptoms are generally milder. Also, tumor markers like alpha-fetoprotein (AFP) tend to be higher in primary liver cancer, whereas in secondary liver cancer, this marker may be normal.