Is primary liver cancer hereditary?

Written by Peng Li Bo
Oncology
Updated on November 24, 2024
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Primary liver cancer is usually not hereditary, but the reason why it tends to appear in families in China is mainly due to the widespread infection of hepatitis B virus, which then leads to a significant correlation with hepatic cirrhosis caused by hepatitis B. It is well known that the hepatitis B virus is contagious and can easily be transmitted within families and from mother to child. Therefore, it is not uncommon to see several cases of liver cancer within the same family, indicating a familial aggregation. Another factor is related to dietary habits, for example, the infection of aflatoxin, which is mainly found in moldy peanuts. If the dietary habits within a family are similar, then, of course, the likelihood of occurrence is certainly higher.

Other Voices

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Can early-stage liver cancer be cured by resection?

Liver cancer is one of the common malignant tumors of the digestive system. For patients with early-stage liver cancer, clinical cure is possible after curative surgery. This clinical cure refers to instances where liver cancer patients, after undergoing curative surgery, do not show signs of recurrence or metastasis over a period exceeding five years. This means there is no invasion of surrounding tissues and no metastasis to distant organs – effectively, the patients have achieved clinical cure. Patients' survival time exceeds five years, or even longer. Therefore, for patients with early-stage liver cancer, because their lesions are relatively limited, achieving clinical cure is possible following curative surgery. However, as the disease progresses to the mid and late stages, even with aggressive surgery and postoperative adjuvant radiotherapy or chemotherapy, most patients cannot achieve clinical cure.

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Does early-stage liver cancer metastasize?

Patients with early-stage liver cancer generally do not experience metastasis. This is because for patients with early-stage liver cancer, the lesions are localized and have not spread, thus being classified as early-stage. Moreover, the general treatment for patients with early-stage liver cancer involves curative surgery. Since the lesions are localized, in most cases, there will be no recurrence or metastasis after the surgery. Therefore, for early-stage patients, there is no need to administer adjuvant radiotherapy or adjuvant chemotherapy and other anti-tumor treatments after the surgery. However, once the liver cancer lesions invade surrounding tissues and metastasize to distant sites, it indicates that the lesions have spread, and the clinical stage has progressed to mid or late stages, losing the opportunity for curative surgery. Most patients undergo comprehensive treatments such as radiotherapy, chemotherapy, and targeted therapy which generally results in a reduction in survival time.

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Is primary liver cancer contagious?

Primary liver cancer refers to malignant tumors that occur in the liver and are not metastasized from other parts of the body. Such liver cancer itself is not contagious. However, if liver cancer patients have other infectious diseases, transmission may be possible. Most primary liver cancers are related to liver cirrhosis following hepatitis, with hepatitis B being the most common. If accompanied by hepatitis B, it can be contagious, but it usually doesn't spread through regular daily contact. The main transmission routes for hepatitis B are through blood, mother-to-child transmission, and sexual transmission. This means that as long as the patient's blood does not injure someone else, contagion is generally unlikely, so there is no need for excessive worry.

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What's going on with the facial swelling in the late stage of liver cancer?

Patients with advanced liver cancer may experience facial swelling, which can be attributed to the following reasons: Firstly, patients with advanced liver cancer often show significant disease progression and may develop complications associated with hepatorenal syndrome. Clinically, this can manifest as reduced urine output, anuria, and even renal impairment, leading to facial swelling. Secondly, in patients with advanced liver cancer, there may be metastasis to cervical lymph nodes. Enlarged lymph nodes can compress or invade surrounding structures, leading to superior vena cava syndrome. Once this syndrome occurs, patients may experience swelling in the face and neck, and some may even face severe breathing difficulties. Lastly, some patients with advanced liver cancer may experience renal damage due to the toxic side effects of antitumor treatments or medications. Clinically, this can lead to increased levels of blood urea nitrogen and creatinine, reduced urine output, and hypoproteinemia, which may also result in facial swelling.

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Can liver calcifications be liver cancer?

Calcification in the liver is not liver cancer. For internal liver calcifications, it is described in ultrasonography and CT scans as a benign lesion, not as liver cancer. Liver cancer is a malignant tumor that can be life-threatening, thus it is considered a serious condition. When calcification is present, it is not indicative of liver cancer, but regular follow-up ultrasounds are still needed to monitor changes in size dynamically. If the calcification increases significantly in size over a short period and grows rapidly, malignant transformation should be suspected, and surgery should be conducted as soon as possible to improve the prognosis for the patient. Additionally, for liver cancer patients, it is advisable to avoid spicy and irritating foods to reduce inflammatory stimulation, which is more conducive to the recovery of the condition.