Is primary liver cancer prone to metastasis?

Written by Sun Wei
Surgical Oncology
Updated on September 25, 2024
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Primary liver cancer's likelihood of metastasis depends on its pathological staging. If detected in the middle or late stages, it is more likely to metastasize. The most common sites of metastasis for primary liver cancer include intrahepatic and nearby digestive organs, such as the gastrointestinal tract and the peritoneum. Additionally, primary liver cancer can also spread through the bloodstream and the lymphatic system, reaching distant locations like the lungs, brain, and bones. If primary liver cancer cannot be surgically treated, the treatment options are limited, and the survival time is generally short, with an average lifespan of about one to two years.

Other Voices

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Written by Yan Chun
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Does early-stage liver cancer metastasize?

Patients with early-stage liver cancer generally do not experience metastasis. This is because for patients with early-stage liver cancer, the lesions are localized and have not spread, thus being classified as early-stage. Moreover, the general treatment for patients with early-stage liver cancer involves curative surgery. Since the lesions are localized, in most cases, there will be no recurrence or metastasis after the surgery. Therefore, for early-stage patients, there is no need to administer adjuvant radiotherapy or adjuvant chemotherapy and other anti-tumor treatments after the surgery. However, once the liver cancer lesions invade surrounding tissues and metastasize to distant sites, it indicates that the lesions have spread, and the clinical stage has progressed to mid or late stages, losing the opportunity for curative surgery. Most patients undergo comprehensive treatments such as radiotherapy, chemotherapy, and targeted therapy which generally results in a reduction in survival time.

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How to rule out liver cancer when experiencing right shoulder pain?

Some liver cancer patients may experience abdominal pain that radiates to the shoulder and back, resulting in right shoulder pain. Therefore, when a patient presents with right shoulder pain, to rule out the possibility of liver cancer, some laboratory tests or radiological examinations can be conducted, and if necessary, histopathological examinations can also be performed. If hematological examination does not show an abnormal increase in AFP levels, and radiological examinations do not reveal any abnormal liver conditions such as large masses, nodular tumors, or diffuse liver lesions, and there is no history of hepatitis or cirrhosis, it is generally possible to rule out right shoulder pain caused by liver cancer. To determine the exact cause of the pain, examinations such as X-rays of the right shoulder, CT scans, and if necessary, MRI or bone scans can be conducted to exclude right shoulder pain caused by liver cancer lesions.

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Written by Si Li Li
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Can hepatitis B turn into liver cancer?

Hepatitis B can gradually develop into cirrhosis or liver cancer. Therefore, if a hepatitis B virus infection is detected, it needs attention. If the hepatitis B surface antigen is positive in the HBV "two-and-a-half" test, it indicates a hepatitis B virus infection. Once infected with the hepatitis B virus, it is necessary to regularly check liver function and hepatitis B virus DNA, as well as have abdominal ultrasounds. If an increase in transaminases is found, it indicates the transformation into chronic hepatitis B, necessitating liver-protecting and enzyme-lowering treatments. If the hepatitis B virus DNA exceeds a certain value, antiviral treatment is also needed. After being infected with the hepatitis B virus, it is crucial to rest and avoid excessive fatigue and staying up late.

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Does early-stage liver cancer cause itchy skin?

Liver cancer is one of the common malignant tumors in the digestive system. In the early stages of liver cancer, most patients do not exhibit symptoms of skin itching. It is only when the cancer progresses and causes obstructive jaundice that patients clinically develop symptoms of skin itching. Early-stage liver cancer patients typically do not show typical clinical symptoms, or they may not have any significant symptoms at all. This is because early-stage liver cancer lesions are small and localized, without external invasion or metastasis. Therefore, the impact on the entire body is minimal, and clinically it generally manifests as mild abdominal bloating, discomfort, nausea, diarrhea, and some patients may experience a dull ache or discomfort in the liver area. Because the symptoms of early-stage liver cancer are atypical, many patients are already in the middle to late stages by the time they seek medical attention, missing the opportunity for clinical cure.

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Is primary liver cancer hereditary?

The occurrence of tumors is related to multiple factors including genetics, environment, and the lifestyle habits of the patient. Therefore, primary liver cancer does have a genetic component. If parents, siblings, grandparents, etc., have a history of liver cancer, the offspring of such patients might have a higher probability of developing liver cancer compared to the general population. However, it's not absolute, as it also depends on other factors like environment, personal dietary habits, lifestyle habits, whether one has hepatitis, alcoholic liver cirrhosis, and other similar factors. Thus, those with a family history of liver cancer are likely to have a higher risk of developing the condition and should be more vigilant about disease screening. Screening should be more frequent than for the general population, but this is not an absolute rule.