Is Kawasaki disease common?

Written by Yan Xin Liang
Pediatrics
Updated on June 18, 2025
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Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a disease of unknown etiology. Epidemiological data suggest that multiple pathogens such as Rickettsia, Staphylococcus, Streptococcus, retroviruses, and Mycoplasma infections may be the causes, but these have not been confirmed. The incidence of this disease is relatively low worldwide, though it occurs more frequently among Asians. Epidemiological surveys in China from 2002 to 2004 indicated that the incidence rate among children under five in Beijing was 49.4/100,000. Although not particularly high, this incidence rate still makes it a relatively common autoimmune disease. The primary treatments for this disease are intravenous immunoglobulin and aspirin.

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Written by Li Jiao Yan
Neonatology
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How many days can Kawasaki disease be cured?

Kawasaki disease is a syndrome of mucocutaneous lymph node syndrome, the cause of which is unclear, as is the pathogenesis of the disease. The pathological changes are mainly systemic vasculitis, which is prone to secondary damage to the coronary arteries. It has a relatively long course. If fever occurs, the fever can persist for 1-2 weeks. Generally, special medications such as aspirin are required for treatment. Usually, treatment is for 3 days, and after the fever subsides, the dosage is gradually reduced, maintained for 6-8 weeks. If there is secondary coronary artery damage, the duration might be longer. In cases of severe coronary damage, the duration of the disease may be several months or even years, depending on the specific condition of the disease. Kawasaki disease is a self-limiting disease. Usually, if there is no significant coronary artery damage, after symptom control, comprehensive examinations are conducted 1 month, 3 months, 6 months, and 1-2 years after discharge, mainly heart examinations such as electrocardiograms and echocardiograms. If there is a combination of coronary artery aneurysms, long-term follow-up is required, with an examination every six months to one year until the coronary aneurysm disappears or if there is combined damage to the coronary artery structure, long-term follow-up is needed.

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Written by Quan Xiang Mei
Pediatrics
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How to alleviate vomiting in Kawasaki disease

When children with Kawasaki disease experience vomiting, the first step is to refrain from eating and drinking, including water, for one to two hours after vomiting to avoid burdening the stomach and intestines. If vomiting subsides after fasting, there is no need for medication temporarily. However, if there is no significant relief and bloating is evident, it is necessary to treat for bowel movement and gas release. At this time, oral medications that aid in digestion, such as digestive tonics, are acceptable. If relief is still not achieved, intravenous fluid supplementation and medications that enhance gastrointestinal motility can be administered. Parents can also keep the abdomen warm and, centering around the navel, perform clockwise abdominal massages to help alleviate the symptoms of vomiting.

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Written by Li Jiao Yan
Neonatology
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Does Kawasaki disease cause vomiting?

Kawasaki disease is a disease with no clear etiology, commonly seen in infants and toddlers, with eighty percent of cases occurring in children under five years old. Its main pathological change is systemic vasculitis. The main symptoms include fever, congested and cracked lips, diffuse congestion of the oral mucosa, swollen tongue papillae, and strawberry tongue. Other symptoms may include swelling of the hands and feet, polymorphous erythema, and enlarged lymph nodes. There could be subsequent cardiac complications, primarily affecting the coronary arteries. Kawasaki disease may cause vomiting due to the diffuse congestion in the oral cavity, and the pharynx might also be congested. When children experience significant congestion, their laryngeal reflex might be sensitive, possibly leading to vomiting. Furthermore, children with Kawasaki disease might develop secondary infections from other bacteria and viruses, which could also lead to symptoms like vomiting. Therefore, the manifestations of Kawasaki disease can vary, and if significant vomiting occurs, it should be investigated to determine the cause.

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Written by Li Jiao Yan
Neonatology
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Does Kawasaki disease cause a runny nose?

Kawasaki disease, also known as mucocutaneous lymph node syndrome, primarily presents with repeated high fevers that do not respond to antibiotics, conjunctival congestion, diffuse oral congestion, chapped and congested lips, polymorphic erythema and scarlatiniform rashes on the skin, and unilateral or bilateral cervical lymphadenopathy. The cause of Kawasaki disease remains unclear, but studies suggest that respiratory or gastrointestinal infections may be common prodromal symptoms, indicating that the onset might be related to infections, though no contagious phenomena have been identified to date. Kawasaki disease might show prodromal signs such as upper respiratory infections, characterized by symptoms like a runny nose and cough, or gastrointestinal symptoms such as diarrhea and vomiting, which suggests that a runny nose might be a manifestation of Kawasaki disease.

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Written by Yan Xin Liang
Pediatrics
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Kawasaki disease sequelae

Kawasaki disease is an autoimmune vasculitis, and since it is vasculitis, it can originate from blood vessels in various parts, including the heart, liver, kidneys, brain, and more. However, it mainly arises from the coronary arteries of the heart. If Kawasaki disease is not effectively treated, some patients can develop coronary artery dilation and even coronary artery aneurysms. Once a coronary artery aneurysm occurs, its complication includes the risk of rupture and bleeding of the aneurysm, which can be difficult to treat if there is severe bleeding. If there is some coronary artery dilation, it can lead to the formation of coronary artery thrombosis, which is also a complication it can cause. However, the vast majority of Kawasaki disease cases, if treated effectively, can prevent coronary artery abnormalities. Therefore, as long as the treatment is timely, most cases will not have significant lasting effects.