Rickets is a chronic, systemic nutritional disease closely related to lifestyle, caused by a deficiency of vitamin D levels leading to abnormal calcium and phosphorus metabolism in the body. This condition prevents calcium salts from being properly deposited in the growing parts of the skeleton, resulting in incomplete mineralization of the bone tissue during growth and characteristic skeletal deformities. The primary biochemical manifestation of the disease is a decrease in vitamin D levels in the body, particularly a significant reduction in 125-dihydroxyvitamin D3 levels. Gradually, there may also be a decrease in calcium and phosphorus levels in the body and sometimes abnormal parathyroid hormone activity. Generally, rickets is primarily caused by a deficiency of vitamin D, so it is important to timely supplement vitamin D, take appropriate sunbaths, and supplement with calcium as needed based on the situation.