The absence of vaginal discharge during amenorrhea is generally a normal phenomenon, indicating that the amenorrhea is caused by a reduction in estrogen and diminished ovarian function. This condition is commonly seen in endocrine disorders such as hyperprolactinemia or premature ovarian failure. It is necessary to examine the six female sex hormones and thyroid function to confirm the diagnosis.

If the examination reveals elevated prolactin levels, diagnosing hyperprolactinemia, a head CT scan is generally required. If a pituitary tumor is present, surgical treatment should be conducted. If no pituitary tumor is found, treatment with a specific medication like bromocriptine is given, after which menstruation and normal vaginal discharge will resume.

Another scenario is seen in cases of premature ovarian failure, which also leads to amenorrhea and a reduction in vaginal discharge. For premature ovarian failure, a common approach is to use cyclical hormone replacement therapy to restore menstruation and vaginal discharge.