Is aplastic anemia serious?

Written by Li Fang Fang
Hematology
Updated on September 10, 2024
00:00
00:00

Whether aplastic anemia is severe depends on the specific circumstances of the aplastic anemia. Aplastic anemia can be divided into acute aplastic anemia and chronic aplastic anemia. Among them, acute aplastic anemia has a sudden onset, more severe clinical symptoms, and a higher mortality rate, so it is relatively more severe. Chronic aplastic anemia has a slower onset, and the degree of decrease in blood cells is relatively mild, also making it less severe. However, in cases of acute aplastic anemia, if intensive immunotherapy is administered, the effectiveness can reach 60%-70%, and it can be cured through hematopoietic stem cell transplantation.

Other Voices

doctor image
home-news-image
Written by Zhang Xiao Le
Hematology
1min 13sec home-news-image

Are the liver and kidney functions normal in patients with aplastic anemia?

Patients with aplastic anemia generally have normal liver and kidney functions. However, in certain special circumstances, abnormalities in liver and kidney functions may occur, including: Firstly, the routine treatment for aplastic anemia mainly includes the immunosuppressant cyclosporine and the hematopoietic stimulant androgens. The primary side effect of cyclosporine is renal toxicity. Therefore, during the use of cyclosporine, it is necessary to monitor the concentration of cyclosporine; excessive levels can lead to renal dysfunction. Androgens, including stanozolol and danazol, primarily cause hepatic toxicity; hence, it is necessary to monitor liver and kidney functions during treatment of aplastic anemia. The second factor that may cause liver and kidney function abnormalities is severe anemia. Long-term severe anemia can lead to tissue ischemia and hypoxia in the liver or kidneys, and if prolonged, it can cause abnormalities in liver and kidney functions. (Medication use should be carried out under the guidance of a physician.)

doctor image
home-news-image
Written by Zhang Xiao Le
Hematology
42sec home-news-image

Is it good to transfuse platelets for aplastic anemia with low platelets?

Aplastic anemia is a type of bone marrow failure syndrome, with patients often experiencing a decrease in all blood cells in the peripheral blood. As a result, patients typically face a higher risk of infections and bleeding. Treatment for aplastic anemia is a long-term process, and hematopoiesis often cannot be restored quickly. Therefore, especially in severe cases of aplastic anemia, patients' blood cells remain at relatively low levels for an extended period, placing them at severe risk of infections and bleeding. If platelets fall below 20*10^9/L, it is necessary to administer platelet transfusions to prevent severe bleeding.

doctor image
home-news-image
Written by Zhang Xiao Le
Hematology
52sec home-news-image

Does aplastic anemia easily cause oral ulcers?

Patients with aplastic anemia are more prone to oral ulcers. Aplastic anemia is a type of bone marrow failure syndrome, where there is a decrease in white blood cells, red blood cells, and platelets in the peripheral blood to various extents. Long-term anemia can lead to mucosal ischemia and hypoxia. The reduction in white blood cells weakens the mucosal barrier's protective function, making it susceptible to bacterial invasion and thus prone to oral ulcers. Additionally, patients with anemia often have poor diets over long periods, leading to a deficiency in various vitamins, which is another reason why they are prone to oral ulcers. If symptoms like joint pain are present along with oral ulcers, further rheumatological and immunological tests should be conducted to rule out rheumatic and immune system diseases.

doctor image
home-news-image
Written by Li Fang Fang
Hematology
52sec home-news-image

How long can one live with aplastic anemia?

The lifespan of patients with aplastic anemia depends on the type and the effectiveness of the treatment. Aplastic anemia is classified into acute aplastic anemia and chronic aplastic anemia. In cases of acute aplastic anemia, cure is possible through intensified immunotherapy or hematopoietic stem cell transplantation; however, without aggressive treatment, the survival period is relatively short, generally not exceeding one year. Chronic aplastic anemia, on the other hand, has a longer medical history, and patients can often live for ten to twenty years or more. However, throughout this period, ongoing transfusions of red blood cells and platelets are required to support treatment.

doctor image
home-news-image
Written by Li Fang Fang
Hematology
1min home-news-image

Aplastic anemia is a disease.

Aplastic anemia is a bone marrow failure syndrome, which simply means that the bone marrow's function to produce blood cells is impaired, and it cannot produce the blood cells needed by a normal body. Clinically, it manifests as a series of symptoms caused by the reduction of all blood cells. A reduction in white blood cells can lead to infections in various systems, such as fever, cough, sputum, abdominal pain, diarrhea, frequent urination, urgent urination, and pain during urination. A reduction in red blood cells leads to anemia, which can cause symptoms such as dizziness, headache, fatigue, chest tightness, and palpitations. A decrease in platelets can lead to spontaneous bleeding, such as bleeding in the mouth, gums, and nose, and in severe cases, even cerebral hemorrhage.