Aplastic anemia is caused by how?

Written by Li Fang Fang
Hematology
Updated on December 11, 2024
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Aplastic anemia currently still has an uncertain etiology. However, clinical observations have suggested that chemotherapy drugs, viral infections, and radiation exposure might be related to the occurrence and development of aplastic anemia. Regardless of the cause, these factors all involve abnormalities in immune function. Abnormal immune function leads to the occurrence and development of aplastic anemia. Therefore, immunosuppressive therapy is often effective for patients with aplastic anemia in clinical settings. (Medication use should be conducted under the guidance of a professional doctor.)

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Written by Li Fang Fang
Hematology
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The etiology of aplastic anemia

The etiology of aplastic anemia currently has no absolute cause, but the more supported theories concerning its etiology include the soil, pest, and seed theories. The soil theory refers to abnormalities in the microenvironment within the bone marrow, which causes an abnormal growth environment for hematopoietic stem cells, consequently limiting their growth. The seed theory indicates a decrease in the number and quality of hematopoietic stem cells in the bone marrow, leading to bone marrow regeneration failure. The pest theory refers to immunological factors, which play a significant role in aplastic anemia, suggesting a disorder in the patient's immune function that leads to bone marrow regeneration failure.

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Written by Li Fang Fang
Hematology
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Does aplastic anemia cause fever?

Aplastic anemia itself does not cause fever in patients; however, individuals with aplastic anemia experience a decrease in all blood cells, including white blood cells, red blood cells, and platelets. A significant reduction in white blood cells, such as in a state of neutropenia, can lower a patient's resistance to infections, which makes it easy for secondary infections to occur and thus induce fever. Furthermore, in cases of severe anemia, severe aplastic anemia can also lead to the occurrence of low-grade fever in patients. On the other hand, a reduction in platelets generally does not cause fever. Therefore, when a patient with aplastic anemia has a fever, it is important to determine the cause of the fever.

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Written by Li Fang Fang
Hematology
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Aplastic anemia is caused by how?

Aplastic anemia currently still has an uncertain etiology. However, clinical observations have suggested that chemotherapy drugs, viral infections, and radiation exposure might be related to the occurrence and development of aplastic anemia. Regardless of the cause, these factors all involve abnormalities in immune function. Abnormal immune function leads to the occurrence and development of aplastic anemia. Therefore, immunosuppressive therapy is often effective for patients with aplastic anemia in clinical settings. (Medication use should be conducted under the guidance of a professional doctor.)

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Written by Zhang Xiao Le
Hematology
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Are the liver and kidney functions normal in patients with aplastic anemia?

Patients with aplastic anemia generally have normal liver and kidney functions. However, in certain special circumstances, abnormalities in liver and kidney functions may occur, including: Firstly, the routine treatment for aplastic anemia mainly includes the immunosuppressant cyclosporine and the hematopoietic stimulant androgens. The primary side effect of cyclosporine is renal toxicity. Therefore, during the use of cyclosporine, it is necessary to monitor the concentration of cyclosporine; excessive levels can lead to renal dysfunction. Androgens, including stanozolol and danazol, primarily cause hepatic toxicity; hence, it is necessary to monitor liver and kidney functions during treatment of aplastic anemia. The second factor that may cause liver and kidney function abnormalities is severe anemia. Long-term severe anemia can lead to tissue ischemia and hypoxia in the liver or kidneys, and if prolonged, it can cause abnormalities in liver and kidney functions. (Medication use should be carried out under the guidance of a physician.)

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Written by Li Fang Fang
Hematology
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Can aplastic anemia have children?

Acute aplastic anemia, after effective immunotherapy and discontinuation of medication for more than two years, or after hematopoietic stem cell transplantation and discontinuation of medication for more than two years, it is possible to have children. In cases of chronic aplastic anemia, due to long-term oral intake of immunosuppressants and hematopoietic stimulants, having children is not advised. However, if immunosuppressants and hematopoietic drugs are effective and discontinued for more than two years, and blood levels are acceptable, then it is possible to have children.