Late-stage symptoms of Parkinson's disease

Written by Zhang Hui
Neurology
Updated on April 14, 2025
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Parkinson's disease is a progressively worsening neurodegenerative disorder of the nervous system, initially manifesting as bradykinesia, resting tremor, and other symptoms. As the disease progresses, the symptoms become increasingly severe. In the later stages, symptoms may include significant postural and gait abnormalities, such as obvious stooping and difficulty starting to walk, a phenomenon known as freezing, and turning around can also be difficult. Additionally, in the late stages, swallowing dysfunction may occur, leading to clinical signs such as coughing while drinking water and articulation disorders. Furthermore, individuals with Parkinson's disease are particularly prone to falling in the later stages due to impaired balance functions.

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Written by Zhou Yan
Geriatrics
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Early symptoms of Parkinson's disease

The clinical manifestations of Parkinson's disease are divided into two major categories. One category includes motor symptoms related to damage to the dopaminergic system. The other category includes non-motor symptoms related to damage to non-dopaminergic systems. The non-motor symptoms of Parkinson's disease can appear at various stages, especially before the onset of motor symptoms, such as loss of smell, rapid eye movement sleep behavior disorder, constipation, and depression, which are often early symptoms of the disease. However, because the onset of the disease in patients is relatively hidden, the initial symptoms are often tremors, but can also be bradykinesia or stiffness, with the majority of these cases being diagnosed based on these symptoms. Therefore, when a patient has loss of smell, constipation, depression, or sleep behavior disorder, the possibility of Parkinson's tremor paralysis should be considered.

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Written by Zhou Yan
Geriatrics
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What should be avoided in the diet for Parkinson's disease?

For patients with Parkinson's disease, we advocate comprehensive treatment and full-course management. Drug treatment is the core treatment method, while surgical treatment can supplement drug therapy. Physical rehabilitation and psychological therapy should also be conducted. What should patients with Parkinson's disease avoid eating? Generally, patients with Parkinson's disease are prone to constipation. Therefore, we should avoid consuming spicy and greasy foods that may lead to constipation, and try to eat vegetables and fruits to keep the bowel movements regular.

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Written by Liu Shi Xiang
Neurology
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Early symptoms of Parkinson's disease

The early symptoms of Parkinson's disease primarily include weakness of limbs on one side, resting tremors, and bradykinesia, among others. As the disease progresses, patients will display typical Parkinson's symptoms, including a shuffling gait, reduced facial expressions, decreased sense of smell, orthostatic hypotension, anxiety and depression, cognitive decline, constipation, frequent urination, etc. Therefore, when these symptoms appear, the possibility of Parkinson's disease should be considered. Patients need to promptly visit the neurology department of a hospital for complete testing such as routine blood tests, urinalysis, MRI of the skull, and if necessary, cerebrospinal fluid analysis through lumbar puncture to confirm the diagnosis. Once diagnosed, treatment with anti-Parkinson's medication should be started as soon as possible. Commonly used medications include Levodopa, dopamine receptor agonists, monoamine oxidase inhibitors, Vitamin B6, and more.

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Written by Zhang Hui
Neurology
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Can Parkinson's disease be cured?

Firstly, it must be noted that Parkinson's disease is a neurodegenerative disease which currently cannot be cured. Although Parkinson's disease cannot be cured, there are many methods available to slow the progression of the disease and improve the quality of life for patients. Patients must take medication regularly under the guidance of a doctor. The treatment methods for Parkinson's disease mainly include: First, patients should strengthen their functional training and engage in as much physical activity and exercise as possible, which can help in treating the disease. Second, regular medication is necessary, mainly referring to drugs used for treating Parkinson's disease. These include dopamine receptor agonists, anticholinergic drugs, and Levodopa preparations, all of which can have good effects, but these medications also have certain side effects and require regular follow-up visits at outpatient clinics. (Specific medications should be taken under the guidance of a physician.)

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Written by Zhang Hui
Neurology
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Can Parkinson's disease be cured?

Parkinson's disease is a movement disorder, and there are many medications and treatments that can improve the quality of life for patients and alleviate their clinical symptoms. However, from the current medical perspective, it is impossible to achieve a complete cure. Therefore, patients with Parkinson's disease must not be deceived and should seek treatment at accredited hospitals. Currently, treatment for this disease primarily involves pharmacotherapy. There are various medications available, commonly including dopamine receptor agonists, Levodopa-based drugs, as well as some amantadine and anticholinergic drugs. Each drug has its own characteristics and should be chosen based on the patient's condition. Additionally, some patients in the middle or later stages may also undergo deep brain stimulation surgery to improve symptoms. (Please use medication under the guidance of a professional physician and do not medicate blindly.)