How to medicate for the rigidity in Parkinson's disease?

Written by Zhang Hui
Neurology
Updated on September 11, 2024
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Parkinson's disease presents with rigidity, mainly due to increased muscle tone and muscle rigidity, which is a very important clinical manifestation of Parkinson's disease. The medications used for rigidity in Parkinson's disease mainly include the following types. The first type is dopamine receptor agonists, which can improve limb muscle rigidity to some extent and delay the progression of the disease. The second type of medication is levodopa preparations, which are currently the gold standard for treating Parkinson's disease. Many patients experience significant clinical improvement after taking the medication. The third type of medication includes some anticholinergic drugs. These drugs are particularly effective against tremors and also have some effect in improving rigidity. Medication for Parkinson's disease must be taken under the guidance of a doctor. It is also important to note that levodopa preparations should be taken on an empty stomach or two hours after a meal for better efficacy.

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Written by Zhang Hui
Neurology
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Late-stage symptoms of Parkinson's disease

Parkinson's disease is a progressively worsening neurodegenerative disorder of the nervous system, initially manifesting as bradykinesia, resting tremor, and other symptoms. As the disease progresses, the symptoms become increasingly severe. In the later stages, symptoms may include significant postural and gait abnormalities, such as obvious stooping and difficulty starting to walk, a phenomenon known as freezing, and turning around can also be difficult. Additionally, in the late stages, swallowing dysfunction may occur, leading to clinical signs such as coughing while drinking water and articulation disorders. Furthermore, individuals with Parkinson's disease are particularly prone to falling in the later stages due to impaired balance functions.

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Written by Zhang Hui
Neurology
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Is Parkinson's disease scary?

Parkinson's disease is not a terrifying disease, as its onset is relatively hidden and slow, with gradual progression. Many patients can significantly improve their symptoms, prolong their lives, and enhance their quality of life through rehabilitation training and medication. However, there is no effective cure for Parkinson's disease at this time; current treatments only relieve symptoms and improve quality of life. Patients with Parkinson's should not be afraid and must regularly visit neurology outpatient clinics for follow-up. Neurologists will provide appropriate medications for Parkinson’s and guide the daily life of patients. Moreover, patients must prevent falls. Parkinson's is not a terrifying disease; what is dangerous is arbitrarily stopping or reducing medication without listening to the doctor's advice. (Note: This answer is for reference only, medication should be taken under the guidance of a professional physician, and medications should not be taken blindly.)

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Written by Zhang Hui
Neurology
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Early symptoms of Parkinson's disease

Parkinson's disease in its early stages may primarily manifest as clumsiness in limb movement, especially in fine motor skills, such as difficulty in wrapping dumplings, rolling dumpling wrappers, or slow buttoning, which are clinical signs of early symptoms. Some patients may initially experience slight trembling in the limbs, which is generally more pronounced during rest and relaxation and diminishes during activity. Additionally, some individuals with early Parkinson's disease primarily exhibit non-motor symptoms, such as constipation, depression, reduced sense of smell, and may also experience rapid eye movement sleep behavior disorder, characterized by shouting and physical actions like punching or kicking during sleep.

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Written by Zhang Hui
Neurology
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Can Parkinson's disease be cured?

Parkinson's disease is a degenerative disease of the nervous system that currently cannot be cured in medicine. It is important to choose the right treatment plan to avoid being deceived. Parkinson's disease is mainly caused by the irreversible death of dopaminergic neurons in the substantia nigra, resulting in clinical manifestations such as bradykinesia, muscular rigidity, and tremors in limbs. Other non-motor symptoms include reduced sense of smell, constipation, anxiety, depression, and orthostatic hypotension. Treatment primarily focuses on symptomatic relief, and it is not expected to achieve complete remission. Commonly used medications include levodopa, anticholinergics, and activators of levodopa and dopamine receptors. Symptoms in patients usually progressively worsen, and curing the disease is very difficult.

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Written by Zhou Yan
Geriatrics
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Can Parkinson's disease be cured?

The core treatment for Parkinson's disease currently is pharmacotherapy, with surgical treatment serving as a supplement. Additionally, physical rehabilitation and psychological therapy are also recommended. The most effective drugs against Parkinson's at present include Levodopa, or compound Levodopa preparations. Other treatments include dopamine receptor agonists, monoamine oxidase inhibitors, amantadine, anticholinergic drugs, and catechol-O-methyl transferase inhibitors. Furthermore, there are treatments aimed at non-motor symptoms, such as psychiatric symptoms, cognitive impairments, autonomic dysfunctions, and sleep disorders. For drug treatments, it is advisable to start with a low dose and gradually increase to an appropriate dosage while maintaining the medication regimen. Currently, we cannot cure Parkinson's disease; we can only provide relief to the symptoms and slow the progression of the disease through comprehensive treatment. (The use of medications should be under the guidance of a doctor.)