How does one get Parkinson's disease?

Written by Zhang Hui
Neurology
Updated on September 05, 2024
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Parkinson's disease is a degenerative disease of the nervous system. The actual mechanism of the disease is not very clear, and its fundamental cause has not yet been identified. It is generally believed that Parkinson's disease is mainly caused by the following factors. First, genetic factors. Some cases of Parkinson's disease have a clear familial tendency, where patients may experience mutations in synaptic nuclear protein genes, leading to abnormal aggregation of these proteins. This abnormal aggregation can damage the neurons in the substantia nigra of the midbrain, leading to Parkinson's disease. Second, there are some external factors related to sporadic cases of Parkinson's. These may be closely related to oxidative stress, trauma, poisoning, or an excessive stress response of the body. However, the specific cause is not very clear. Parkinson's disease, which causes symptoms such as bradykinesia, tremors, and rigidity, requires active treatment to improve the quality of life of the patients.

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Written by Zhou Yan
Geriatrics
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Parkinson's disease skin symptoms

In Parkinson's disease, there are two main types of clinical manifestations. One is motor symptoms associated with damage to the dopaminergic system, and the other is non-motor symptoms related to damage of non-dopaminergic systems. The non-motor symptoms include olfactory dysfunction, sleep disorders, mood disorders, as well as cognitive and psychiatric behavioral disturbances. Additionally, there are dysfunctions of the autonomic nervous system, which manifest in the gastrointestinal tract mainly as constipation, and in the urinary system as urinary incontinence, urinary frequency, urinary retention, and sexual dysfunction. There also occurs orthostatic hypotension, along with changes in the skin. Some patients may experience abnormal increases or decreases in sweating and abnormal secretion of sebum in the facial area, which are specific skin symptoms of Parkinson's disease.

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Written by Zhang Hui
Neurology
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Where to treat Parkinson's disease

Parkinson's disease is a very common neurodegenerative disease in neurology. Therefore, if Parkinson's disease is suspected, treatment can be sought in the neurology department, which is available in most hospitals. Many neurologists have extensive experience in treating Parkinson's disease. The treatment primarily includes medication and surgery. Medication therapy mainly refers to the administration of anticholinergic drugs or dopamine receptor agonists, as well as preparations of Levodopa. These medications can help improve symptoms, such as reducing muscle rigidity and tremors. Surgical treatment mainly refers to deep brain stimulation, which is suitable for patients who have been clearly diagnosed with Parkinson's disease for over five years and whose primary symptom is tremor, without significant dementia.

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Written by Zhang Hui
Neurology
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What to do about constipation in Parkinson's disease?

Among Parkinson's disease patients, constipation is a very common clinical symptom. In fact, many patients have experienced constipation for many years before the onset of Parkinson's disease symptoms, mainly due to the impact on some autonomic nerves in the intestines. For Parkinson's patients experiencing constipation, the main suggestions are: First, be sure to drink plenty of water. Drinking enough water can sufficiently lubricate the intestines and facilitate smoother bowel movements. Second, be sure to eat plenty of fresh vegetables and fruits. Vegetables and fruits are rich in vitamin C and can promote gastrointestinal motility. Additionally, it is recommended for patients to eat more bananas, as bananas have an evident laxative effect. Also, eat less of certain foods that can dry out the stool, such as sweet potatoes and chestnuts. If necessary, patients can be given laxative medications, and if bowel movements are extremely difficult, enemas can also be administered.

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Written by Zhou Yan
Geriatrics
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Initial symptoms of Parkinson's disease

The early symptoms of Parkinson's disease are divided into motor symptoms and non-motor symptoms. The onset of Parkinson's disease is relatively concealed and progresses gradually. The initial symptoms can be tremors, bradykinesia, or rigidity, occurring asymmetrically. It often starts in one upper limb and can initially appear in the lower limbs in a few cases, gradually extending to the limbs on the other side. Non-motor symptoms can occur at any stage of Parkinson's disease, including before motor symptoms arise, such as loss of smell, rapid eye movement sleep behavior disorder, constipation, and depression. These are often precursory symptoms of Parkinson’s disease, but such non-motor symptoms can also appear in other diseases, which can make them difficult to clearly distinguish.

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Written by Zhou Yan
Geriatrics
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What are the symptoms of Parkinson's disease?

The main symptoms of Parkinson's disease are divided into two major categories: motor symptoms and non-motor symptoms. The motor symptoms include bradykinesia and hypokinesia, specifically characterized by slow movement speed and reduced amplitude. In daily life, this results in clumsiness with actions such as difficulty standing up, small arm swings while walking, or even no swinging at all, a lack of facial expressions, and progressively smaller handwriting. The second type is resting tremor, which includes pill-rolling movements along with muscle rigidity and postural and gait imbalances, such as a panicked gait or taking very small steps that accelerate and become faster without the ability to stop or turn promptly. Non-motor symptoms include issues such as olfactory dysfunction, sleep disturbances, constipation, and depression.