What are the symptoms of Parkinson's disease?

Written by Zhou Yan
Geriatrics
Updated on March 10, 2025
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The main symptoms of Parkinson's disease are divided into two major categories: motor symptoms and non-motor symptoms. The motor symptoms include bradykinesia and hypokinesia, specifically characterized by slow movement speed and reduced amplitude. In daily life, this results in clumsiness with actions such as difficulty standing up, small arm swings while walking, or even no swinging at all, a lack of facial expressions, and progressively smaller handwriting. The second type is resting tremor, which includes pill-rolling movements along with muscle rigidity and postural and gait imbalances, such as a panicked gait or taking very small steps that accelerate and become faster without the ability to stop or turn promptly. Non-motor symptoms include issues such as olfactory dysfunction, sleep disturbances, constipation, and depression.

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Written by Zhou Yan
Geriatrics
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What is the best way to exercise for Parkinson's disease?

Patients with Parkinson's disease should undergo comprehensive treatment and full management. Drug treatment is the core treatment plan, but it is also necessary to include physical rehabilitation and psychological therapy. For physical therapy, patients should be encouraged to exercise more, as this can help improve symptoms and slow the progression of the disease. The type and intensity of exercise should be chosen based on the patient's motor symptoms. Tai Chi, jogging, brisk walking, and aerobics are all suitable forms of exercise, and it is advisable to exercise four times a week, with each session lasting about 30 minutes. Evidence has shown that Tai Chi can improve patients' balance disorders, and long-term persistence in exercise can help improve their quality of life.

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Written by Zhang Hui
Neurology
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What is needed to diagnose Parkinson's disease?

The definitive diagnosis of Parkinson's disease primarily relies on the patient's medical history, clinical manifestations, and a thorough physical examination by a neurologist. If the onset of the disease is very slow, presenting with symptoms such as bradykinesia and tremors, and the neurologist observes heightened muscle tone and slow movements during the examination, a high suspicion of this disease is warranted. Additionally, certain auxiliary tests are necessary, commonly including: First, testing the patient's sense of smell is crucial, as a reduced sense of smell is very important in diagnosing Parkinson's disease. Second, some brain MRI scans are needed mainly to exclude some secondary Parkinson's syndromes. Third, a brain PET-CT scan can be performed to examine the functionality of the striatum. Furthermore, an ultrasound of the substantia nigra in the midbrain can also be conducted, which holds significant value in assisting the diagnosis.

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Written by Zhang Hui
Neurology
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Can people with Parkinson's disease drink alcohol?

Patients with Parkinson's disease should not drink alcohol. This is primarily due to concerns that due to the symptoms of movement slowness and muscle rigidity, they may exhibit abnormal postural balance, greatly increasing the risk of falling. Consuming alcohol can inhibit the function of the cerebellum, exacerbating limb ataxia and increasing the risk of falling, which poses significant risks to the patient. Therefore, to protect the balance function of patients and prevent the risk of falling, they should not consume alcohol. Additionally, patients with Parkinson's disease often need to take multiple medications for their condition, and these medications should not be taken with alcohol to avoid exacerbating any adverse reactions.

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Written by Zhou Yan
Geriatrics
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The causes of Parkinson's disease

Parkinson's disease, also known as tremor paralysis, is a common neurodegenerative disorder. The cause of Parkinson's disease is not yet clear, but it may be related to several factors, such as aging, genetics, and environmental factors. Since Parkinson's disease is the result of multiple factors, including abnormal protein aggregation, oxidative stress, mitochondrial damage, inflammation, and excitotoxicity of glutamate, these elements lead to the loss of dopaminergic neurons in the substantia nigra of the midbrain and a reduction in dopamine neurotransmitters in the striatum. This ultimately results in the patient's bradykinesia, muscle rigidity, and resting tremor.

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Written by Zhang Hui
Neurology
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Is tremor Parkinson's disease?

Tremor and Parkinson's disease are two completely different concepts. Tremor is not necessarily Parkinson's disease, and Parkinson's disease does not necessarily involve tremor. Tremor is just a clinical symptom that can appear in many diseases. In addition to Parkinson's disease, there are also some essential tremors which are genetic. Patients usually experience tremors in their hands when maintaining certain postures, and may also have head tremors. This is a relatively benign disease with a generally good prognosis. Additionally, patients with hyperthyroidism may also experience limb tremors, but this is not Parkinson's disease. Moreover, many patients with Parkinson's disease experience bradykinesia and rigidity, and might not necessarily have limb tremors. Therefore, these two concepts are different; tremor is not necessarily Parkinson's disease.