Initial symptoms of Parkinson's disease

Written by Zhou Yan
Geriatrics
Updated on April 13, 2025
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The early symptoms of Parkinson's disease are divided into motor symptoms and non-motor symptoms. The onset of Parkinson's disease is relatively concealed and progresses gradually. The initial symptoms can be tremors, bradykinesia, or rigidity, occurring asymmetrically. It often starts in one upper limb and can initially appear in the lower limbs in a few cases, gradually extending to the limbs on the other side. Non-motor symptoms can occur at any stage of Parkinson's disease, including before motor symptoms arise, such as loss of smell, rapid eye movement sleep behavior disorder, constipation, and depression. These are often precursory symptoms of Parkinson’s disease, but such non-motor symptoms can also appear in other diseases, which can make them difficult to clearly distinguish.

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Written by Zhang Hui
Neurology
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Early symptoms of Parkinson's disease.

Parkinson's disease is a relatively common degenerative disease in the elderly, primarily causing the death of dopamine neurons in the substantia nigra of the midbrain, leading to corresponding clinical manifestations. Research has confirmed that other systems may also be damaged in the early stages of Parkinson's disease symptoms. The early symptoms may primarily include: First, patients experience persistent constipation, which is a very important early symptom of Parkinson's disease. Second, some patients may experience sleep disturbances, mainly characterized by tossing and turning, shouting out loud during sleep, without being aware of it. Additionally, some patients in the early stages may also experience a reduced sense of smell, constipation, cognitive impairment, and other clinical manifestations. There are also some early motor symptoms, mainly that the patient becomes clumsy and inflexible in the movements of one side of the body. These are the early symptoms of Parkinson's disease.

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Written by Zhang Hui
Neurology
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Early symptoms of Parkinson's disease

Parkinson's disease in its early stages may primarily manifest as clumsiness in limb movement, especially in fine motor skills, such as difficulty in wrapping dumplings, rolling dumpling wrappers, or slow buttoning, which are clinical signs of early symptoms. Some patients may initially experience slight trembling in the limbs, which is generally more pronounced during rest and relaxation and diminishes during activity. Additionally, some individuals with early Parkinson's disease primarily exhibit non-motor symptoms, such as constipation, depression, reduced sense of smell, and may also experience rapid eye movement sleep behavior disorder, characterized by shouting and physical actions like punching or kicking during sleep.

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Written by Zhang Hui
Neurology
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Is Parkinson's disease scary?

Parkinson's disease is not a terrifying disease, as its onset is relatively hidden and slow, with gradual progression. Many patients can significantly improve their symptoms, prolong their lives, and enhance their quality of life through rehabilitation training and medication. However, there is no effective cure for Parkinson's disease at this time; current treatments only relieve symptoms and improve quality of life. Patients with Parkinson's should not be afraid and must regularly visit neurology outpatient clinics for follow-up. Neurologists will provide appropriate medications for Parkinson’s and guide the daily life of patients. Moreover, patients must prevent falls. Parkinson's is not a terrifying disease; what is dangerous is arbitrarily stopping or reducing medication without listening to the doctor's advice. (Note: This answer is for reference only, medication should be taken under the guidance of a professional physician, and medications should not be taken blindly.)

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Written by Zhang Hui
Neurology
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Is Parkinson's disease dangerous?

Parkinson's disease is a chronic condition and a progressive degenerative disorder of the nervous system. The main symptoms include slowed movements, increased muscle tone, resting tremors, and abnormal posture and gait. The onset of the disease is slow and subtly worsens over time. Although not highly dangerous in itself and not directly life-threatening, Parkinson’s disease currently lacks a cure, and the condition gradually worsens. Generally, within about 10 to 20 years, patients may experience significant balance impairments. The main risks involve instability while walking, which can lead to falls and potentially cause fractures and other complications. In later stages, patients often become bedridden, leading to possible complications such as pulmonary infections, urinary tract infections, bedsores, and malnutrition. Therefore, Parkinson's disease is relatively mild, manageable in the early stages, but requires careful attention in later stages to prevent complications and avoid unnecessary harm.

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Written by Zhou Yan
Geriatrics
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Can people with Parkinson's disease eat honey?

Parkinson's disease, also known as paralysis agitans, is a common neurodegenerative disease of the nervous system. Clinically, it is primarily characterized by symptoms such as bradykinesia, muscle rigidity, and resting tremors, as well as non-motor symptoms such as loss of smell. Patients with paralysis agitans also experience autonomic dysfunction, commonly manifesting as constipation due to slowed intestinal peristalsis. These symptoms can appear 10 to 20 years before the motor symptoms and may include lack of appetite, nausea, vomiting, and increased salivation. For patients with paralysis agitans, consuming honey is beneficial as it can help alleviate constipation by softening the stool and facilitating bowel movements, due to the reduced intestinal motility.