Patients with diabetic nephropathy who experience swelling in their feet often have significant amounts of protein in their urine or may have already developed renal failure. While there are ways to manage foot swelling, the fundamental issues may not be resolved. For swelling, diuretics can be used to increase urine output. If diuretics are ineffective, hemodialysis may be employed to ultrafiltrate and remove excess fluid from the body and alleviate swelling. However, these measures only address the symptoms on the surface. For patients with diabetic nephropathy, the underlying causes are due to diabetes, oxidative stress, and high blood sugar states, which damage the kidneys. Currently, there is no specific clinical treatment for these fundamental issues.