When patients with diabetic nephropathy reach the advanced stage, they actually already have severe renal failure. Prior to this, patients generally exhibit noticeable proteinuria. Continued progression of the disease will lead to the destruction of most of the renal tissues, causing renal failure. This condition is quite serious; patients often experience significant edema, even severe generalized edema. The accumulation of a large amount of fluid in the body leads to an increase in blood volume, and both the preload and afterload on the heart increase, often accompanied by symptoms of heart failure. When patients experience heart failure, they may find it impossible to lie flat and may experience chest tightness, shortness of breath, and difficulty breathing after activity, potentially endangering their lives.