How to reduce proteinuria in diabetic nephropathy.

Written by Zhou Qi
Nephrology
Updated on November 14, 2024
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A major clinical feature of diabetic nephropathy is the occurrence of proteinuria, which, if the condition continues to progress, can lead to kidney failure. Controlling proteinuria in the early stages of the disease is indeed very important. In terms of treatment, it is primarily necessary to use medications or insulin to control the patient's blood sugar, as hyperglycemia is the fundamental cause of diabetic nephropathy. Additionally, these patients often also have hypertension, necessitating the use of antihypertensive drugs to control blood pressure. When the patient's kidney function is not severely impaired, ACE inhibitors or ARBs can be the preferred choice of antihypertensive drugs, as they not only control blood pressure but also reduce proteinuria. However, if the patient's serum creatinine is significantly elevated, such as over 264 µmol/L, these drugs should no longer be used. (Medications should be used under the guidance of a doctor.)

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Written by Zhou Qi
Nephrology
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How to check for diabetic nephropathy?

For the examination of diabetic nephropathy, patients first need to undergo routine urinalysis and check for the urinary albumin excretion rate. Generally speaking, one characteristic of diabetic nephropathy is the presence of urinary protein. A urinary albumin excretion rate between 20 and 200 µg/min is an important basis for diagnosing early diabetic nephropathy. If a patient’s urinary albumin excretion rate consistently exceeds 200 µg/min, significant diabetic nephropathy is often considered. Of course, this is under the assumption that the patient has had diabetes for at least ten years and has diabetic retinopathy. A kidney biopsy is needed for confirmation. Of course, to assess the impact of diabetic nephropathy on kidney function, blood tests for serum creatinine and urea nitrogen are necessary.

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Symptoms of diabetic nephropathy anemia

Patients with diabetic nephropathy who exhibit anemia indicate that they are experiencing relatively severe renal failure. Such patients may show clear clinical symptoms, such as significant edema, excessive proteinuria, and renal failure. The impaired water excretion can lead to swelling in the lower limbs and facial area. The presence of anemia causes fatigue in patients, potentially leading to chronic ischemia and hypoxia in some organs. Symptoms such as listlessness and drowsiness may occur. In the state of anemia due to diabetic nephropathy, the accumulation of metabolic waste may also affect the patient's appetite, causing poor food intake. Additionally, diabetic damage to the retinal arteries can lead to a decline in vision, or even complete blindness.

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Nephrology
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How is diabetic nephropathy treated?

The treatment of diabetic nephropathy also depends on the specific stage the patient is in. During stages one to three, the main clinical treatments include controlling blood sugar, blood pressure, and lipids. Patients with diabetes often also have these metabolic disorders, including hypertension and hyperlipidemia, which can damage the kidneys. In addition, in the early stages, some medications are often chosen to reduce the pressure on the glomeruli. For example, using ACE inhibitors or angiotensin receptor blockers (ARBs) and inhibitors of the sodium-glucose cotransporter, these drugs can also slow the progression of kidney failure. However, if the patient's condition has progressed to stage five, which is essentially equivalent to the state of uremia, the patient will then need dialysis treatment.

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Nephrology
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Which department to see for diabetic nephropathy?

In principle, patients with diabetic nephropathy should seek treatment in the nephrology department of a formal public hospital. Diabetes occurs when there is an absolute deficiency or relative insufficiency in insulin secretion, leading to a state characterized by high blood sugar and various metabolic waste disorders. Such a syndrome can cause damage to multiple organs. The kidneys are a major target organ for damage, and as kidney disease develops, patients may experience proteinuria and potentially progress to renal failure. Therefore, to treat and protect kidney function, it is advised that patients with diabetic nephropathy seek care in the nephrology department of a formal public hospital, where nephrologists can devise a more reasonable treatment plan.

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Can diabetic nephropathy cause blood in urine?

Diabetes-induced kidney damage primarily affects the glomeruli, leading to hardening and narrowing of glomerular blood vessels. Clinically, this is manifested by proteinuria, starting with small amounts of urinary protein and progressively increasing to large amounts, ultimately causing renal failure. Generally, hematuria is rare during the course of diabetic nephropathy. If a patient with diabetic nephropathy experiences hematuria, and the cause is unexplained, it is generally recommended that the patient undergo procedures such as a kidney biopsy to further clarify the cause. It is possible that the patient may have other forms of glomerulonephritis, or an ultrasound of the urinary system should be performed to rule out common causes of blood in the urine, such as urinary system stones or tumors.