Characteristics of Nephrotic Syndrome

Written by Zhang Hui
Nephrology
Updated on September 26, 2024
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The characteristics of nephrotic syndrome are defined by significant proteinuria, where significant proteinuria refers to urinary protein exceeding 3.5 grams in 24 hours; hypoproteinemia, which refers to blood albumin levels below 30 grams per liter; edema, which may present in facial and lower limbs, and even severe patients may exhibit generalized edema around both lower limbs; and hyperlipidemia, characterized by increased cholesterol and triglycerides in the blood. These patients may exhibit reduced urine output, edema, and noticeably increased foam in the urine.

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Written by Zhou Qi
Nephrology
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Does nephrotic syndrome cause itchy skin?

Nephrotic syndrome generally does not cause itchy skin in patients. In patients with nephrotic syndrome, the glomerular filtration barrier is severely damaged, leading to a significant presence of urinary protein and edema, but itchy skin is a rare clinical symptom. If a patient experiences itchy skin, it is recommended to visit the dermatology department of a standard hospital. As such patients may have a disordered immune system, they are prone to various skin issues, such as allergic dermatitis and eczema, which might cause symptoms of itchy skin. However, these are not directly related to nephrotic syndrome.

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Written by Zhou Qi
Nephrology
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Causes of vomiting in nephrotic syndrome

Patients with nephrotic syndrome may experience vomiting for several possible reasons. First, nephrotic syndrome causes severe edema in patients, including edema of the gastrointestinal tract. This state of edema may lead to reduced gastrointestinal motility and symptoms of nausea and vomiting. Furthermore, patients with nephrotic syndrome have low plasma protein levels and poor immune function, making them prone to infections. If there is an infection in the gastrointestinal tract, patients may exhibit clinical symptoms of vomiting as well as potentially experiencing diarrhea, abdominal pain, and so on. Additionally, some patients experience vomiting due to the side effects of medications used during the treatment of nephrotic syndrome.

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Written by Zhang Hui
Nephrology
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Characteristics of Nephrotic Syndrome

The characteristics of nephrotic syndrome are defined by significant proteinuria, where significant proteinuria refers to urinary protein exceeding 3.5 grams in 24 hours; hypoproteinemia, which refers to blood albumin levels below 30 grams per liter; edema, which may present in facial and lower limbs, and even severe patients may exhibit generalized edema around both lower limbs; and hyperlipidemia, characterized by increased cholesterol and triglycerides in the blood. These patients may exhibit reduced urine output, edema, and noticeably increased foam in the urine.

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Written by Zhou Qi
Nephrology
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Precursors of relapse of nephrotic syndrome

Nephrotic syndrome is characterized by patients having 24-hour urinary protein quantification exceeding 3.5g and blood plasma albumin levels lower than 30g/L. This condition can be long-lasting. Some patients, after treatment, can have their condition effectively controlled, but there is still a possibility of relapse. Such relapses often occur after the patient has been overworked or has caught a cold, but there are also some patients who do not have such triggers. When the condition relapses, the urinary protein level increases again, which might lead to an increase in urine foam. Patients might experience significant swelling in the lower limbs and face among other areas, suggesting a relapse of nephrotic syndrome, and it is important to go to the hospital for relevant tests promptly.

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Written by Zhou Qi
Nephrology
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Why does nephrotic syndrome cause sleepiness?

Excessive sleepiness is not a common clinical manifestation of nephrotic syndrome; generally, patients with nephrotic syndrome rarely exhibit excessive sleepiness. If a patient does display sleepiness, it is necessary to investigate the causes, such as a reduction in blood volume and decreased blood pressure caused by nephrotic syndrome, leading to insufficient cerebral blood supply. Furthermore, in cases of nephrotic syndrome, the patient’s immune capacity decreases, making them more susceptible to various infections, such as infections of the upper respiratory tract and lungs. When inflamed, patients are also likely to feel excessively sleepy. In some patients, there is a risk of cerebral infarction, which can also cause sleepiness.