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IgA nephropathy
How is IgA nephropathy caused?
IgA nephropathy is a common glomerular disease and a major cause of uremia. However, the exact cause of IgA nephropathy is not very clear. Current research suggests that it is caused by factors such as infections which stimulate the production of autoantibodies, forming immune complexes that deposit in the glomeruli. This leads to inflammation of the glomeruli, eventually stimulating mesangial cell proliferation and accumulation of extracellular matrix, causing glomerulosclerosis and interstitial fibrosis. IgA nephropathy is a very covert disease, often presenting as asymptomatic hematuria or increased urine protein. Many patients discover this condition incidentally during physical examinations. Some individuals have a history of upper respiratory or gastrointestinal infections before the onset of the disease, followed by the discovery of gross hematuria. IgA nephropathy is more common in children and adolescents.
Can IgA nephropathy stage 2 be cured?
IgA nephropathy is an immunopathological diagnostic term for chronic glomerulonephritis, indicating that the patient has chronic nephritis. In fact, chronic nephritis does not have a concept of complete cure. Stage two patients indicate that the inflammatory reaction within the glomerulus is not very severe, but the patient may also show more proteinuria. In most cases, the renal function of these patients is still normal, and it may be necessary to decide whether to choose medications such as corticosteroids based on the amount of proteinuria. If the patient responds well to medication, the proteinuria may significantly decrease, or even turn negative, but it cannot be completely cured, as this is a chronic disease, and there is also a possibility of relapse in the later stages of the disease. (Please follow the doctor's orders regarding medication use.)
Is IgA nephropathy grade 3 serious?
IgA nephropathy is divided into five stages pathologically, with stage three being the focal proliferative type. The higher the stage, the more severe the condition of IgA nephropathy. Stage three is in the early to middle phase, where generally the condition of the patients is comparatively good, and rarely worsens to uremia, belonging to the low-risk group. Clinically, patients with stage three IgA nephropathy often exhibit repeated occurrences of gross hematuria or persistent microscopic hematuria. Some patients may also experience varying degrees of increased urinary protein. Patients with this stage of IgA nephropathy rarely suffer from hypertension or renal insufficiency, but it is essential in daily life to avoid nephrotoxic drugs, prevent infections, seek medical attention promptly upon infection, and regularly follow up on routine urine and renal function changes. If the condition tends to worsen, active treatment should be pursued.
Can patients with IgA nephropathy eat beef?
Diet plays a very important role in the treatment of IgA nephropathy patients. For IgA nephropathy patients, the general dietary requirement is to eat a light diet, avoid spicy foods, and avoid fried foods. IgA nephropathy patients can eat beef. Beef contains animal protein, which is a high-quality protein with essential amino acids that are easily absorbed and utilized by the human body. Of course, if IgA nephropathy patients have normal kidney function, there aren't too many restrictions on their diet compared to healthy individuals. They should mainly consume fresh vegetables and fruits, and avoid pickles, salty vegetables, and fermented vegetables. If there is accompanying kidney dysfunction, it is advisable to minimize the intake of plant proteins and limit the consumption of plant-based proteins such as soy products.
IgA nephropathy stages 1, 2, 3 criteria
According to the standards of the World Health Organization, IgA nephropathy is classified into five stages pathologically. The first stage is where most glomeruli appear normal under light microscopy, with only minor mesangial proliferation or associated cellular proliferation, generally showing slight changes without damage to the tubules and interstitium; The second stage indicates mild lesions where over fifty percent of the glomeruli are normal, with only a small portion of the glomeruli showing mesangial cell proliferation, glomerular sclerosis adhesion, and other changes, without the formation of crescents; The third stage is focal segmental glomerulonephritis, characterized by diffuse proliferation of mesangial cells and widening of the mesangial areas, with the lesions exhibiting focal segmental changes and comparatively mild interstitial lesions.
How is IgA nephropathy diagnosed?
The diagnosis of IgA nephropathy relies on pathological examination. The name "IgA nephropathy" itself is a term used in immunopathological diagnosis, describing a type of chronic glomerulonephritis. There are many reasons that can cause inflammatory reactions in the kidneys, and the underlying mechanisms of the disease vary. Specifically, IgA nephropathy refers to the abnormal deposition of IgA immune complexes in the mesangial areas of the glomeruli. Therefore, a pathological examination is necessary for diagnosis. Typically, under a light microscope, proliferation of mesangial cells and widening of the mesangial areas can be observed. Additionally, immunofluorescence testing is conducted to detect a large presence of IgA immune complexes in the glomerular mesangial areas, confirming the diagnosis of IgA nephropathy.
How to treat occult blood in IgA nephropathy
IGA disease is a pathological type of chronic glomerulonephritis. This type of glomerular lesion often leads to positive occult blood in urine, and in some cases, may even cause gross hematuria visible to the naked eye. However, the relationship between hematuria and the severity or prognosis of the patient's condition is not very clear, so clinically, hematuria is not considered as a treatment target. Generally, during the active phase of the disease, patients can be treated with corticosteroids and other medications, especially those with more than 1g of protein in a 24-hour urine collection. Otherwise, most patients choose ACE inhibitors or ARBs as antihypertensive drugs to reduce the pressure inside the glomerulus. Additionally, avoiding colds can also help reduce occult blood in urine. (Specific medications should be administered under the guidance of a physician)
Kidney disease IgA means IgA nephropathy.
Kidney disease IgA, formally known as IgA nephropathy, is an immunological diagnostic term for chronic glomerulonephritis. It is characterized by the deposition of immune complexes, primarily IgA, in the mesangial areas of the glomeruli. IgA is a type of immunoglobulin, which upon deposition in the kidneys induces inflammatory responses, leading to proliferation of mesangial cells, accumulation of mesangial matrix, and widening of the mesangial area. This can cause damage to the glomerular filtration barrier, manifesting as proteinuria and hematuria. Some patients may also develop crescent formations in the glomeruli, leading to renal failure.
IgA nephropathy is a kidney disease.
In medical terms, there is a condition named IgA nephropathy. IgA is actually a type of immunoglobulin. The function of immunoglobulins is to bind with antigens, which then induces an inflammatory response. For example, when bacteria enter the human body, the combination of IgA with the bacteria guides the body's immune system to target and attack the bacteria, which is a normal scenario. This IgA immunoglobulin acts as a mediator in the immune response. Due to some defect, this substance accumulates in the glomeruli. Its deposition in the glomerular capillaries can trigger inflammation in these blood vessels, leading to IgA nephropathy. This results in proliferation of glomerular mesangial cells, deposition in the mesangial matrix, causing blood and protein in the urine, and even leading to renal failure.
What will happen if someone with IgA nephropathy stays up late?
IgA nephropathy is a very common glomerular disease in clinical settings and is one of the main causes of uremia. IgA nephropathy is most commonly seen in adolescents, particularly in males. The cause of IgA nephropathy is currently unclear, but the clinical manifestations of patients with IgA nephropathy are numerous and vary in severity. For patients with milder IgA nephropathy, it is important to maintain a healthy lifestyle, avoid staying up late, overworking, and infections. Frequently staying up late can aggravate the condition, leading to significant proteinuria and even worsening kidney function. Therefore, it is crucial for patients with IgA nephropathy to regularly monitor their urinalysis, kidney function, and blood pressure, maintain a regular lifestyle, and avoid various adverse lifestyle impacts. Of course, once the condition worsens, it is important to seek medical attention promptly and pursue active treatment.