Is IgA nephropathy grade 3 serious?

Written by Li Liu Sheng
Nephrology
Updated on December 12, 2024
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IgA nephropathy is divided into five stages pathologically, with stage three being the focal proliferative type. The higher the stage, the more severe the condition of IgA nephropathy. Stage three is in the early to middle phase, where generally the condition of the patients is comparatively good, and rarely worsens to uremia, belonging to the low-risk group. Clinically, patients with stage three IgA nephropathy often exhibit repeated occurrences of gross hematuria or persistent microscopic hematuria. Some patients may also experience varying degrees of increased urinary protein. Patients with this stage of IgA nephropathy rarely suffer from hypertension or renal insufficiency, but it is essential in daily life to avoid nephrotoxic drugs, prevent infections, seek medical attention promptly upon infection, and regularly follow up on routine urine and renal function changes. If the condition tends to worsen, active treatment should be pursued.

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Written by Zhou Qi
Nephrology
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IgA nephropathy is a kidney disease.

In medical terms, there is a condition named IgA nephropathy. IgA is actually a type of immunoglobulin. The function of immunoglobulins is to bind with antigens, which then induces an inflammatory response. For example, when bacteria enter the human body, the combination of IgA with the bacteria guides the body's immune system to target and attack the bacteria, which is a normal scenario. This IgA immunoglobulin acts as a mediator in the immune response. Due to some defect, this substance accumulates in the glomeruli. Its deposition in the glomerular capillaries can trigger inflammation in these blood vessels, leading to IgA nephropathy. This results in proliferation of glomerular mesangial cells, deposition in the mesangial matrix, causing blood and protein in the urine, and even leading to renal failure.

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Written by Zhou Qi
Nephrology
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Kidney disease IgA means IgA nephropathy.

Kidney disease IgA, formally known as IgA nephropathy, is an immunological diagnostic term for chronic glomerulonephritis. It is characterized by the deposition of immune complexes, primarily IgA, in the mesangial areas of the glomeruli. IgA is a type of immunoglobulin, which upon deposition in the kidneys induces inflammatory responses, leading to proliferation of mesangial cells, accumulation of mesangial matrix, and widening of the mesangial area. This can cause damage to the glomerular filtration barrier, manifesting as proteinuria and hematuria. Some patients may also develop crescent formations in the glomeruli, leading to renal failure.

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Written by Li Liu Sheng
Nephrology
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Foods to Avoid with IgA Nephropathy

IgA nephropathy patients are a very common type of glomerular disease. For IgA nephropathy patients, it is crucial to adhere to a light diet, meaning they should avoid foods such as pickles, salted vegetables, kimchi, cured products, smoked products, and barbecues, focusing primarily on fresh vegetables and fruits. Of course, if IgA nephropathy patients also suffer from renal insufficiency, they must avoid various soy products including tofu, bean sprouts, soybean sprouts, mung bean sprouts, and nut-based foods. These foods contain a lot of plant proteins, which can increase the burden on the kidneys, leading to potential renal insufficiency. Additionally, they should not consume foods high in potassium, such as oranges, bananas, pineapples, etc. Therefore, it is essential for IgA nephropathy patients to be cautious with their diet.

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Written by Zhou Qi
Nephrology
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IgA kidney disease causes

IgA nephropathy is a type of chronic nephritis. Patients with this disease have inflammatory reactions within their glomeruli. This inflammation is caused by the deposition of IgA immune complexes in the glomeruli. The reason why patients are prone to IgA immune complex deposition is still not very clearly explained in current medical literature and remains unclear. It is possible that such patients produce defective IgA immunoglobulins, often related to mucosal inflammatory infections, such as tonsillitis, enteritis, proctitis, etc. Inflammation of these mucosal areas might cause defective secretory IgA to circulate through the bloodstream to the kidneys, triggering an inflammatory response. The production of defective IgA immunoglobulins in patients may be related to genetic and environmental factors, but the specific mechanism is still not very clear.

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Written by Li Liu Sheng
Nephrology
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IgA nephropathy stages 1, 2, 3 criteria

According to the standards of the World Health Organization, IgA nephropathy is classified into five stages pathologically. The first stage is where most glomeruli appear normal under light microscopy, with only minor mesangial proliferation or associated cellular proliferation, generally showing slight changes without damage to the tubules and interstitium; The second stage indicates mild lesions where over fifty percent of the glomeruli are normal, with only a small portion of the glomeruli showing mesangial cell proliferation, glomerular sclerosis adhesion, and other changes, without the formation of crescents; The third stage is focal segmental glomerulonephritis, characterized by diffuse proliferation of mesangial cells and widening of the mesangial areas, with the lesions exhibiting focal segmental changes and comparatively mild interstitial lesions.