Depression is not contagious, but there is a certain genetic predisposition to it. Clinically, depression is closely related to genetic, environmental, physiological, and psychological factors. For families with a history of depression, their offspring are 4-8 times more likely to suffer from depression than the general population. However, this does not mean depression is a hereditary disease. Interaction with individuals suffering from depression may influence others negatively, including feelings of sadness, self-blame, or despair. Nevertheless, depression cannot be transmitted to others. Through systematic and standardized treatment, particularly with the use of new antidepressant medications, depression can be effectively managed.