Systemic lupus erythematosus symptoms

Written by Yang Ya Meng
Rheumatology
Updated on November 24, 2024
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The symptoms of systemic lupus erythematosus mainly include fever, oral ulcers, facial erythema, including discoid and malar rash, photosensitivity, joint pain, polyserositis, including pleural effusion and pericardial effusion, as well as kidney involvement. The main manifestations are positive urinary protein, hematuria, and casts in the urine. Severe cases may have neurological involvement, presenting as epilepsy, mental disorders, or altered consciousness. Blood tests in these patients can further reveal positive ANA, anti-double-stranded DNA, and anti-Sm antibodies, as well as low complement levels. These are the related symptoms of systemic lupus erythematosus.

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Written by Li Jing
Rheumatology
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Can systemic lupus erythematosus become pregnant?

Firstly, systemic lupus erythematosus is a multisystemic, systemic autoimmune disease that can involve multiple organs throughout the body. Regarding the issue of whether one with systemic lupus erythematosus can become pregnant, it cannot be generalized and must be considered in conjunction with the condition of the disease. For example, if the disease is in its early stages and has been stabilized through treatment, then it is possible to become pregnant. If systemic lupus erythematosus has already presented with severe complications, such as lupus nephritis, significant proteinuria, or an increase in creatinine urea, affecting kidney function and causing kidney damage, then it is not recommended to become pregnant during this period. Pregnancy at this time not only offers no substantial benefit to the person with systemic lupus erythematosus but can also increase the burden on the kidneys, leading to further deterioration of kidney function, which can be life-threatening.

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Written by Yang Ya Meng
Rheumatology
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What to do if systemic lupus erythematosus causes a fever?

Patients with systemic lupus erythematosus (SLE) who develop a fever first need to discern whether the fever is due to immune-related fever caused by the activity of the disease or an infectious fever due to weakened immunity from long-term use of steroids and immunosuppressants. If the fever is caused by lupus activity, then it is necessary to increase the dosage of corticosteroids in treatment. If the fever is due to an infection, a full course of anti-infection treatment is needed. The anti-infection regimen may even need to include treatments with antibacterial, antifungal, and antiviral medications. (Please follow professional medical advice for medication use, and do not self-medicate.)

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Written by Li Jing
Rheumatology
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What medication is used for systemic lupus erythematosus?

Systemic lupus erythematosus is a global autoimmune disease that can involve multiple systems and organs. The cause of the disease is unclear, and it cannot be completely cured; it can only be managed through medication. However, once the condition stabilizes, the medication dosage can be gradually reduced and maintained at a low dose. The preferred treatment is corticosteroids, but if there is damage to other organs, such as pulmonary interstitial fibrosis or renal damage and proteinuria, it is necessary to combine immunosuppressants. This is done to prevent recurrence of the disease and to manage complications that may arise during the reduction of steroids. Additionally, it is crucial to be cautious about sun protection, avoid oral contraceptives, and prevent exposure to cold and overexertion. (Please take medication under the guidance of a doctor.)

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Written by Yang Ya Meng
Rheumatology
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What should be done if systemic lupus erythematosus causes a fever?

If patients with systemic lupus erythematosus develop a fever, it is first necessary to determine whether the fever is caused by poor control of systemic lupus erythematosus, leading to an immune-related fever, or if it is due to the patient's long-term use of corticosteroids and immunosuppressants, resulting in decreased resistance and an acute infection, thus causing the fever. If the fever is immune-related, it will be necessary to strengthen treatment with corticosteroids and immunosuppressants. If the fever is due to an infection, regular anti-infection treatment will be required, which sometimes includes antifungal, antibacterial, and antiviral therapies. (The use of medications should be carried out under the guidance of a doctor)

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Written by Li Jing
Rheumatology
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Systemic lupus erythematosus is a disease.

Firstly, systemic lupus erythematosus is a chronic disease. It is an autoimmune disease that can affect multiple systems and organs and cannot be cured. It can only be controlled over the long term with medication. The goals of comprehensive treatment are to control symptoms, prevent relapses, slow the progression of the disease, and provide symptomatic treatment. Because this disease cannot be cured, it is important to avoid sun exposure, overwork, and getting chilled in daily life to prevent triggering or worsening the condition. Particularly in women, it is crucial to avoid oral contraceptives.