How is ankylosing spondylitis treated?

Written by Yang Ya Meng
Rheumatology
Updated on March 17, 2025
00:00
00:00

The treatment of ankylosing spondylitis mainly consists of three types:

The first is anti-inflammatory pain relief, primarily using non-steroidal pain relief medications, such as sustained-release diclofenac sodium tablets.

The second is the selection of disease control medications, mainly involving drugs like sulfasalazine tablets.

For ankylosing spondylitis, the most effective and economically expensive treatment is biological agents therapy. We commonly use drugs such as tumor necrosis factor antagonists. Patients with ankylosing spondylitis during acute pain periods are advised not to engage in intense exercise. However, during remission periods, appropriate functional exercises are recommended to prevent the adhesion and stiffness of spinal joints.

Other Voices

doctor image
home-news-image
Written by Li Jing
Rheumatology
1min 16sec home-news-image

What injections are used for ankylosing spondylitis?

Firstly, ankylosing spondylitis is an autoimmune disease primarily characterized by the destruction of axial joints, a chronic condition that can also manifest peripheral joint lesions. Currently, there are no definitive cures, meaning long-term medication is necessary to alleviate symptoms, control disease progression, delay joint deformity, reduce disability, and improve quality of life. This constitutes the overall goal of treatment. The preferred treatments are non-steroidal anti-inflammatory drugs (NSAIDs) and biologic agents. However, before using biologic agents, it is essential to complete routine blood tests, erythrocyte sedimentation rate, C-reactive protein, screenings for infectious diseases, and tuberculosis. After excluding infections, tuberculosis, and tumors, biologic agents can be administered. During the use of biologic agents, there is a risk of reduced immunity, making it easy to contract infections. Therefore, it is important to avoid getting cold, overwork, and to regularly recheck routine blood parameters, liver, and kidney functions.

doctor image
home-news-image
Written by Yang Ya Meng
Rheumatology
1min 8sec home-news-image

What medicine is used for ankylosing spondylitis?

The medication for ankylosing spondylitis mainly involves three aspects. The first is non-steroidal pain-relief medications, commonly including drugs like sustained-release diclofenac sodium tablets. The second involves drugs that control the condition, commonly using medications like sulfasalazine and thalidomide. The third, which is currently the most effective, involves treatment with biologics. Common biologics include tumor necrosis factor inhibitors. However, before using biologics, it is crucial to rigorously rule out complications such as hepatitis, tuberculosis, and tumors. Only after excluding these conditions should one consider using biologics. Patients with ankylosing spondylitis should also pay attention to appropriate functional exercises in daily life to prevent the stiffening of spinal joints. (Medications should be used under the guidance of a doctor, based on the specific situation.)

doctor image
home-news-image
Written by Li Jing
Rheumatology
47sec home-news-image

What should I do in the late stage of ankylosing spondylitis?

Firstly, ankylosing spondylitis is an autoimmune disease primarily affecting the axial joints, but it can also present with extra-articular manifestations. Severe cases can lead to ankylosis and deformities of the spine, which are complications of late-stage ankylosing spondylitis. At this stage, surgery is needed to manage the activity of the disease. If the activity of the disease is not controlled, even joint replacement can still lead to the progression of the disease and further damage to the joint structures. For severe disabling deformities, spinal orthopedic surgery can be considered, and spinal surgery is required when an acute fracture occurs.

doctor image
home-news-image
Written by Guan Jing Tao
Orthopedics
37sec home-news-image

How to exercise with ankylosing spondylitis

In the early stages of ankylosing spondylitis, when the impact on the sacral and other joints is minimal, normal activities such as swimming and jogging are acceptable. However, in the later stages of ankylosing spondylitis, as the disease progressively affects the sacral, hip, and knee joints, it becomes necessary to adjust the exercise regimen, mainly focusing on walking. It is important to avoid localized exposure to the cold and to take oral medications that nourish the joint cartilage. Daily local heat therapy for the joints or appropriate acupuncture can also help to some extent in delaying the erosion and damage of the joints by ankylosing spondylitis.

doctor image
home-news-image
Written by Sun Shu Jian
Orthopedics
47sec home-news-image

Early symptoms of ankylosing spondylitis

The initial symptoms of ankylosing spondylitis mainly manifest as morning stiffness in the back. Then, there appears to be pain in the back and hip joints. The pain is generally more noticeable at night, and patients often wake up at night due to back pain. Pain can be significantly relieved after light activity. Early ankylosing spondylitis generally does not have characteristic clinical manifestations. A definitive diagnosis requires physical examinations, imaging studies, and blood tests. After confirming the diagnosis, timely and standard treatment is needed. Treatment can control the inflammation and pain of the synovium, prevent the further development of the disease, and prevent deformities of the spine and joints.