How is ankylosing spondylitis treated?

Written by Yang Ya Meng
Rheumatology
Updated on March 17, 2025
00:00
00:00

The treatment of ankylosing spondylitis mainly consists of three types:

The first is anti-inflammatory pain relief, primarily using non-steroidal pain relief medications, such as sustained-release diclofenac sodium tablets.

The second is the selection of disease control medications, mainly involving drugs like sulfasalazine tablets.

For ankylosing spondylitis, the most effective and economically expensive treatment is biological agents therapy. We commonly use drugs such as tumor necrosis factor antagonists. Patients with ankylosing spondylitis during acute pain periods are advised not to engage in intense exercise. However, during remission periods, appropriate functional exercises are recommended to prevent the adhesion and stiffness of spinal joints.

Other Voices

doctor image
home-news-image
Written by Li Jing
Rheumatology
1min 6sec home-news-image

Does ankylosing spondylitis cause buttock pain?

Ankylosing spondylitis may cause buttock pain. It primarily affects the axial joints, and can be accompanied by extrarticular manifestations. This condition leads to stiffening and deformity of the spine, and it cannot be cured, only managed with medication to slow the progression of the disease, delay joint deformity, improve quality of life, and reduce disability rates. Its clinical manifestations vary widely, and its onset is often insidious. Men are more commonly affected and tend to experience more severe symptoms. The most common symptoms include stiffness in the neck or pain in the lumbar and back areas. However, some people may experience pain in the lower back, accompanied by morning stiffness, or alternating pain in the buttocks, or radiating pain from the groin to the lower limbs. This pain is often worse at night or after prolonged sitting, but symptoms can lessen after activity.

doctor image
home-news-image
Written by Li Jing
Rheumatology
1min 16sec home-news-image

What injections are used for ankylosing spondylitis?

Firstly, ankylosing spondylitis is an autoimmune disease primarily characterized by the destruction of axial joints, a chronic condition that can also manifest peripheral joint lesions. Currently, there are no definitive cures, meaning long-term medication is necessary to alleviate symptoms, control disease progression, delay joint deformity, reduce disability, and improve quality of life. This constitutes the overall goal of treatment. The preferred treatments are non-steroidal anti-inflammatory drugs (NSAIDs) and biologic agents. However, before using biologic agents, it is essential to complete routine blood tests, erythrocyte sedimentation rate, C-reactive protein, screenings for infectious diseases, and tuberculosis. After excluding infections, tuberculosis, and tumors, biologic agents can be administered. During the use of biologic agents, there is a risk of reduced immunity, making it easy to contract infections. Therefore, it is important to avoid getting cold, overwork, and to regularly recheck routine blood parameters, liver, and kidney functions.

doctor image
home-news-image
Written by Li Jing
Rheumatology
1min 10sec home-news-image

How long does ankylosing spondylitis take to cause paralysis?

Ankylosing spondylitis is an autoimmune disease and a chronic condition. It primarily involves damage to the axial joints. Additionally, extrajoint manifestations can occur, such as iritis, keratitis, and corneal perforation. Currently, there is no effective cure for ankylosing spondylitis, meaning it cannot be completely cured. The treatment focuses on long-term medication management to control symptoms, delay complications, improve quality of life, and reduce disability rates. This is the main goal of treatment. Without proper treatment, deformities in the joints and spinal ankylosis can develop within a relatively short period, about seven to eight years, leading to a hunched back and significant restriction in joint mobility. Proper treatment can significantly delay joint damage. Regarding whether ankylosing spondylitis can lead to paralysis, it does not cause paralysis but does result in decreased energy and ability for activities such as turning, twisting the head, or bending, which are significantly restricted.

doctor image
home-news-image
Written by Guan Jing Tao
Orthopedics
37sec home-news-image

How to exercise with ankylosing spondylitis

In the early stages of ankylosing spondylitis, when the impact on the sacral and other joints is minimal, normal activities such as swimming and jogging are acceptable. However, in the later stages of ankylosing spondylitis, as the disease progressively affects the sacral, hip, and knee joints, it becomes necessary to adjust the exercise regimen, mainly focusing on walking. It is important to avoid localized exposure to the cold and to take oral medications that nourish the joint cartilage. Daily local heat therapy for the joints or appropriate acupuncture can also help to some extent in delaying the erosion and damage of the joints by ankylosing spondylitis.

doctor image
home-news-image
Written by Li Jing
Rheumatology
55sec home-news-image

How is ankylosing spondylitis diagnosed?

Ankylosing spondylitis is an autoimmune disease that cannot be cured but can be managed primarily through medication. Its main typical symptoms include stiffness in the neck or pain in the lower back, with the pain becoming more apparent when at rest or after sitting for a long time. Symptoms tend to improve with movement. A typical occurrence is pain that awakens the patient at night. Peripheral joints like the knee joint and heel can also be affected. However, the main symptoms are stiffness in the neck and pain in the lower back. Diagnosing ankylosing spondylitis requires combining symptoms with a positive B27 blood test result, and imaging tests such as CT or MRI of the sacroiliac joints, showing signs of sacroiliitis, narrowing or damage in the sacroiliac joint space, to confirm the diagnosis.