How is glioma graded?

Written by Jiang Fang Shuai
Neurosurgery
Updated on September 02, 2024
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According to the characteristics of pathology, gliomas are divided into grades one to four. Grade one is a low-grade malignancy, more benign tumor, accounting for about 5%, with a relatively high probability of successful surgical outcomes. Grade two accounts for about 35%, and after comprehensive treatment including surgery, the survival rate can reach five to ten years, or even longer. Grade three usually develops from grade two, with relatively poor prognosis, and the average survival period is about two years. Grade four, the most malignant glioma, also known as glioblastoma, accounts for about 30%-40%, with an average survival period of less than one year, and very poor outcomes.

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Written by Chen Yu Fei
Neurosurgery
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Treatment of brain glioma

For patients with brain gliomas, it is recommended that they visit a local hospital as soon as possible in the early stages of the disease. A physician with extensive surgical experience should help assess the current situation through cranial CT, cranial MRI, and enhanced cranial MRI scans, to determine the location, scope, and range of edema of the glioma, as well as its proximity to surrounding blood vessels and nerves, and to establish a personalized surgical treatment plan. Through surgery, the glioma in the brain should be removed as completely as possible. After surgical treatment, most patients can achieve satisfactory outcomes. However, since gliomas are malignant tumors, it is necessary to follow up surgery with early radiation and chemotherapy treatments.

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Written by Chen Yu Fei
Neurosurgery
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What are the symptoms of glioma?

Patients with gliomas often exhibit a range of symptoms including significant headaches, dizziness, nausea, and vomiting. As the tumor grows, it typically leads to an evident increase in intracranial pressure. Besides the original symptoms, some patients may also experience marked declines in vision, visual field deficits, and papilledema. The growth of the tumor inevitably compresses surrounding tissues, nerves, and blood vessels, leading to a variety of symptoms of neurological damage, such as noticeable hemiplegia, aphasia, and even abnormal sensations in one side of the body, characterized by numbness, pain, and a pins-and-needles sensation.

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Written by Chen Yu Fei
Neurosurgery
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Is glioma a terminal illness?

Glioblastoma is not an incurable disease. Patients with glioblastoma have a type of malignant tumor that tends to grow rapidly. These tumors often adhere to surrounding brain tissue in the early stages, making complete surgical removal difficult. If any glioma cells remain after surgery, the tumor tissue will gradually grow over time. Thus, patients with glioblastoma are prone to recurrence, but it is not an incurable disease. If early detection and surgical removal can be achieved, and supplemented by radiotherapy and chemotherapy, it can maximize the therapeutic effects of the surgery, thereby effectively improving the prognosis and delaying the progression of the disease. This approach can relatively extend the patient's lifespan, and some patients may even achieve long-term survival.

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Written by Chen Yu Fei
Neurosurgery
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The etiology of glioma

At present, there is no definitive conclusion regarding the specific causes of glioma. Clinically, it is generally considered the result of a combination of congenital genetic factors and acquired environmental factors. Usually, it is believed that there is a significant familial aggregation tendency in the family medical history of patients with gliomas, with a higher incidence of gliomas among family members. Additionally, acquired factors, such as severe cranial trauma followed by extensive proliferation of neuroglial cells, may induce incidents. Furthermore, severe intracranial infections, including unhealthy lifestyles, poor living environments, and the influence of radioactive materials, could potentially lead to the occurrence of gliomas.

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Written by Gao Yi Shen
Neurosurgery
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Is a glioma benign or malignant?

Glioblastoma is the most common form of malignant tumor inside the skull, and the vast majority of glioblastomas are highly malignant. Once changes in this condition are detected, generally, the patient doesn't have much time left. If it is a relatively better glioblastoma, which means it is highly differentiated, the survival time is about 1-2 years. For some poorer glioblastomas, or those with low differentiation, their survival period is often only about six months, and they continuously spread along with nerve fibers to the surrounding areas. They might even metastasize to distant places through cerebrospinal fluid, blood, lymph, and other means. Therefore, even if surgery is used to remove a single lesion, other parts of the body may still demonstrate metastatic lesions. Hence, the treatment approach for this is comprehensive.