Glioma Causes

Written by Jiang Fang Shuai
Neurosurgery
Updated on September 02, 2024
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Gliomas are common intracranial primary tumors, with astrocytoma being the most prevalent, followed by oligodendroglioma, medulloblastoma, glioblastoma, ependymoma, etc. The causes of gliomas are very complex and are still unclear to this day. The prevailing view is that the development of gliomas results from the combined effects of internal carcinogenic genes and external carcinogenic factors. Changes in carcinogenic genes include gene mutation deletions, proto-oncogene activation, and so on. External factors mainly include radiation from X-rays, smoking, drinking, and some toxic and harmful foods and medications, etc.

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Written by Chen Yu Fei
Neurosurgery
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What are the symptoms of glioma?

Patients with gliomas often exhibit a range of symptoms including significant headaches, dizziness, nausea, and vomiting. As the tumor grows, it typically leads to an evident increase in intracranial pressure. Besides the original symptoms, some patients may also experience marked declines in vision, visual field deficits, and papilledema. The growth of the tumor inevitably compresses surrounding tissues, nerves, and blood vessels, leading to a variety of symptoms of neurological damage, such as noticeable hemiplegia, aphasia, and even abnormal sensations in one side of the body, characterized by numbness, pain, and a pins-and-needles sensation.

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Neurosurgery
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The etiology of glioma

At present, there is no definitive conclusion regarding the specific causes of glioma. Clinically, it is generally considered the result of a combination of congenital genetic factors and acquired environmental factors. Usually, it is believed that there is a significant familial aggregation tendency in the family medical history of patients with gliomas, with a higher incidence of gliomas among family members. Additionally, acquired factors, such as severe cranial trauma followed by extensive proliferation of neuroglial cells, may induce incidents. Furthermore, severe intracranial infections, including unhealthy lifestyles, poor living environments, and the influence of radioactive materials, could potentially lead to the occurrence of gliomas.

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Written by Gao Yi Shen
Neurosurgery
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Glioma Symptoms

The symptoms of glioma are numerous, and it is essential to make judgments based on the situation. The most common clinical manifestations are headaches, dizziness, nausea, and vomiting. These symptoms may persist for a relatively long period and are relatively mild, not immediately noticeable at the time. Additionally, some patients may experience a decline in cognitive function, colloquially described as becoming less intelligent. This is especially common in gliomas of the frontal lobe. If the glioma is located in the occipital lobe, it often causes visual disturbances, such as blurred vision and visual field defects. In cases of temporal lobe gliomas, frequent seizures and impaired limb mobility may occur. For cerebellar gliomas, symptoms can include a decline in cognitive function and ataxia, among others.

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Written by Gao Yi Shen
Neurosurgery
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Glioma causes

In clinical practice, the etiology of gliomas is not very clear. It is not as straightforward as how smoking can easily lead to lung cancer or how cirrhosis can easily lead to liver cancer; many factors are speculative. For example, the most common theory in clinical practice involves genetics. Any form of genetic mutation or chromosomal mutation can induce the development of a glioma. For instance, excessive radiation exposure and drug abuse, and even maternal-fetal transmission or a genetic predisposition, could cause chromosomal abnormalities in patients, potentially leading to the formation of gliomas. However, the most fundamental cause has not yet been clearly identified.

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Written by Gao Yi Shen
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Is glioma cancer?

Gliomas are the most common type of malignant tumor within the skull, and they are also a form of cancer. Cancer is a very broad term essentially describing a process where some cells proliferate abnormally and differentiate without dying, and gliomas proliferate in the same way. To give an analogy, think of a bunch of villains: if there are heroes to suppress and resolve these villains, then generally, people would not develop tumors. However, if this group of villains gradually becomes stronger and defeats the heroes, then these villains gather within the body, forming a tumor. The same principle applies to the formation of cancer. Therefore, for such cases, it is crucial to detect cancer early and begin the appropriate treatment. Early treatment can have some very beneficial effects on the prognosis for the patient.