Osteoarthritis is a difficult-to-treat disease because currently, there is no complete cure for joint disorders in medicine. Therefore, the treatment principles are early diagnosis, early treatment, and early rehabilitation. Mainly, methods are used to delay the progression of the disease, maximally preserve joint function, and enable patients to live normal lives. The first approach is non-pharmacological treatment, which is the foundation for drug therapy and surgical treatment, primarily involving physical therapy methods such as heat therapy, hydrotherapy, traction, microwave therapy, acupuncture, and massage to alleviate joint pain and swelling during acute flare-ups. The second approach is pharmacological treatment, mainly including non-steroidal anti-inflammatory drugs and traditional Chinese medicine. The third approach involves considering surgical treatment if conservative treatments prove ineffective. Surgical treatments can involve procedures such as joint debridement to remove inflamed, loose cartilage and bone tissues, and smoothing rough joint surfaces. If these methods are still ineffective, the last treatment option may be needed for severe cases, which is artificial joint replacement. Thus, the treatment of osteoarthritis is a stepwise approach. However, regardless of the treatment method used, there is currently no cure, making osteoarthritis a challenging disease to treat.