Causes of Obesity

Written by Tang Zhuo
Endocrinology
Updated on September 19, 2024
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Obesity, also known as adiposis, is a chronic metabolic disease caused by excessive accumulation or abnormal distribution of fat in the body. It results from the interaction of multiple factors including genetic and environmental factors that cause fat accumulation. Primary obesity, also known as simple obesity, is the most common type and is mainly caused by poor dietary habits, such as excessive food intake, particularly excessive fats, and a sedentary lifestyle. There is also secondary obesity, which is generally caused by diseases of the endocrine system. Hormonal treatments for allergic diseases and rheumatic diseases can also lead to secondary obesity.

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Written by Tang Zhuo
Endocrinology
1min 59sec home-news-image

The Harms of Obesity

Mild to moderate primary obesity might not present with noticeable symptoms. However, individuals with severe obesity may experience heat intolerance, reduced physical activity capability, mild shortness of breath during activities, and snoring during sleep. The likelihood of developing coronary heart disease and hypertension is significantly higher in obese individuals compared to those who are not obese. Obesity leads to reduced lung capacity and decreased pulmonary compliance, which can cause various pulmonary functional abnormalities. For instance, obese hypoventilation syndrome, clinically characterized by sleepiness, obesity, and alveolar hypoventilation, often accompanies obstructive sleep apnea. Severe cases of obesity may lead to pulmonary heart syndrome. Obese individuals often experience metabolic disorders of lipids and carbohydrates; lipid metabolism disorders can lead to hypertriglyceridemia and hypercholesterolemia, while carbohydrate metabolism disorders are marked by glucose intolerance and diabetes. Moreover, obese individuals are more prone to arthritis, gout, and osteoporosis. Sexual dysfunction is common in obese individuals, with some obese men developing gynecomastia; obese girls tend to have an earlier onset of menstruation, while adult women with obesity often experience menstrual disorders, and in severe cases, amenorrhea. The incidence of polycystic ovary syndrome is also significantly higher in obese women compared to non-obese women.

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Written by Chen Li Ping
Endocrinology
1min 18sec home-news-image

Will obesity be inherited?

The primary cause of simple obesity, where the reason for being overweight is unclear, is an energy intake that exceeds energy expenditure. There are also certain genetic factors involved. Generally, it is believed that susceptibility to obesity varies among human races, along with the presence of obesity genes and variations in genes related to obesity. Additionally, an individual’s metabolic type, appetite, digestive absorption functions, sleep quality, and metabolic efficiency form the basis for the development of simple obesity. Poor lifestyle habits, such as insufficient physical activity and excessive energy intake, are necessary conditions for its occurrence. Epidemiological surveys have shown that most people with simple obesity have a familial tendency towards the condition. Children born to obese parents are 5-8 times more likely to develop simple obesity than those born to parents who both have a normal weight. However, the majority of cases of simple obesity are not caused by obesity genes or mutations in genes related to obesity.

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Written by Zhang Jun Jun
Endocrinology
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What should people with obesity not eat?

Patients with obesity generally also have elevated blood lipids, elevated blood uric acid, and slightly high blood sugar. Therefore, regarding diet, it is crucial to strictly adhere to a standard of low salt, low fat, and low purine. Avoid eating fried foods and animal offal, and do not consume carbohydrate-rich foods and sugary drinks. Additionally, for patients with high uric acid levels, it is advised not to consume excessive seafood and rich broths. It is recommended to avoid eating late-night meals, fried foods, and grilled items. The foods that should be avoided by patients with obesity are mainly determined based on the levels of blood sugar, blood lipids, blood pressure, and blood uric acid.

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Written by Li Lang Bo
Endocrinology
1min 27sec home-news-image

Causes of Obesity

In the medical field, obesity is categorized into two types: primary (simple) obesity and secondary obesity. Primary obesity occurs without any other physical diseases and is solely due to irregular lifestyle, unscientific eating habits, and lack of exercise, leading to weight gain. This type can be managed with lifestyle adjustments and proper dietary guidance to reduce weight. Secondary obesity, which is less common, often involves endocrine disorders such as Cushing's syndrome. This condition can arise from issues with the pituitary or adrenal glands, or other parts of the body such as tumors, leading to excessive secretion of cortisol. This in turn causes redistribution of body fat, leading to characteristic signs like moon face, buffalo hump, and accumulation of subcutaneous fat which are manifestations of obesity. Additionally, conditions like hypothyroidism can lead to myxedema, contributing to obesity, as well as drug-induced obesity. Examples include patients with nephrotic syndrome or lupus who experience weight gain from prolonged use of corticosteroids. Therefore, the causes are diverse and require differential diagnosis by a specialist based on the individual's condition.

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Written by Tang Zhuo
Endocrinology
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What diseases are people with obesity prone to?

Obesity, also known as adiposis, is a chronic metabolic disease caused by excessive accumulation or abnormal distribution of body fat. It results from the interaction of multiple factors, including genetics and environmental elements. Patients with obesity have a significantly increased incidence of hypertension, coronary heart disease, type 2 diabetes, dyslipidemia, sleep apnea, cholecystitis, cholelithiasis, osteoarticular diseases, and certain tumors and cardiovascular diseases are closely related to obesity.