Diabetic foot primarily involves changes in the blood vessels and nerves of the lower limbs and feet, so early symptoms may include numbness, a feeling of stepping on cotton, and weakness in the legs. Furthermore, pain can manifest as numbness and pain in both soles of the feet, or as vascular and neurological pain in the lower limbs and the inner thighs. If diabetic foot is accompanied by venous thrombosis in the lower limbs or arterial embolism, the resulting pain can affect the entire lower limbs symmetrically and present as intermittent claudication. Therefore, the main sites of pain in diabetic foot are determined by the locations of vascular and nerve damage.