If diabetic foot ulceration occurs, the most important first step is surgical debridement to remove necrotic tissue and thoroughly clean the wound. If the ulceration is particularly severe and there is gangrene, and the foot can no longer be preserved, amputation may even be necessary. Secondly, anti-infection treatment should be administered, choosing sensitive antibiotics. The third step is to control the underlying condition; treatment must control blood sugar levels to avoid hyperglycemia, as high blood sugar serves as a culture medium for bacteria. Fourth, it is necessary to improve local blood circulation; diabetic foot often coexists with arteriosclerosis of the lower limb arteries, even leading to occlusion. Therefore, it is necessary to improve the circulation of local blood vessels and open up the vessels. Fifth, the nutritional treatment of peripheral nerves must be improved. Treatment of diabetic foot is a comprehensive approach.