Osteoporosis is primarily characterized by a reduction in bone mass, deterioration of bone tissue microstructure, and increased bone fragility, leading to an increased risk of fractures. It is a metabolic bone disease. Some cases are primary, also referred to as postmenopausal osteoporosis, which generally lacks specific causes and is mainly linked to estrogen deficiency. There is also a category known as secondary osteoporosis, which has a variety of causes, primarily secondary to metabolic endocrine disorders such as hyperparathyroidism, Cushing's syndrome, diabetes, and growth hormone deficiency. Additionally, some hematologic disorders, such as leukemia and lymphoma, can lead to osteoporosis. There are also some less common or rare diseases like osteogenesis imperfecta and scurvy that can cause osteoporosis. Furthermore, long-term use of certain medications, such as corticosteroids and anticonvulsants, can lead to osteoporosis. Kidney diseases, such as chronic renal failure and renal tubular acidosis, can also cause osteoporosis.