Gallbladder cancer skin itching area

Written by Liu Wu Cai
Hepatobiliary Surgery
Updated on February 22, 2025
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Patients with gallbladder cancer may develop obstructive jaundice as the tumor size increases, which can manifest as yellowing of the skin and mucous membranes, dark urine, and pale stools. Patients may also experience itching and discomfort. For these patients, the treatment effectiveness is generally poor, and gallbladder cancer is a type of malignancy that tends to metastasize and has a very poor prognosis. Once symptoms are prominent, treatment becomes relatively difficult and less effective. It is advisable for gallbladder cancer patients to undergo surgical resection as early as possible to improve their prognosis. However, the onset of gallbladder cancer is often insidious and frequently overlooked.

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Written by Shen Jiang Chao
Radiology
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MRI manifestations of gallbladder cancer

The manifestations of gallbladder cancer on MRI primarily include significant thickening of the gallbladder wall or a mass within the gallbladder. Generally, it appears as low signal on T1-weighted images and high signal on T2-weighted images. After enhancement, the lesion shows obvious enhancement. If the lesion is large, necrosis may occur internally. Since the gallbladder is close to the liver, if abnormal signals are found in the liver, intrahepatic metastasis should be considered, which further confirms the possibility of gallbladder cancer. Additionally, gallbladder cancer can also invade the nearby bile ducts, causing dilation of the bile ducts, as well as local or distant lymph node metastasis.

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Written by Shen Jiang Chao
Radiology
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Gallbladder cancer ultrasonographic appearance

The appearance of gallbladder cancer on color ultrasound depends on the morphology of the cancer, which is mainly divided into five types: small nodular, thick-wall, fragmented, calculous, and mixed type. The small nodular type mainly features a polypoid elevation with a wide base, about 1-1.2 cm in size, and has isoechoic characteristics. The fragmented type is characterized by a wider base and irregular borders, presenting as hypoechoic or isoechoic masses. The calculous type shows an enlarged gallbladder, possibly containing hypoechoic and uneven solid masses that may fill the entire gallbladder. The thick-wall type primarily involves localized or diffuse thickening of the wall. The mixed type is a combination of papillary fragmented type and thick-wall type presence.

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Written by Shen Jiang Chao
Radiology
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The main manifestations of gallbladder cancer on MRI

Gallbladder cancer is more common in females and is generally believed to be associated with chronic stimulation from chronic cholecystitis and gallstones. On MRI, gallbladder cancer can be categorized into several types based on case classification and growth patterns: first, the infiltrative type; second, the nodular type; third, the mass-forming type; and fourth, the obstructive type. Regardless of the pathological type of gallbladder cancer, the tumor tissue appears as a heterogeneous low signal on T1 and a heterogeneous high signal on T2. After enhancement, the tumor shows heterogeneous enhancement. If there is invasion into the liver, the boundary with liver tissue is unclear. MRI has significant advantages in assessing invasion of adjacent organs and metastasis, and can provide great value for surgery or treatment planning.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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Can gallbladder cancer be detected by cancer embryonic antigen test?

The use of cancer embryo antigen in patients with gallbladder cancer has certain reference value, but it is not absolute. Patients with gallbladder cancer typically show a significant increase in embryonic antigen. Gallbladder cancer is difficult to diagnose early as it generally does not show specific symptoms. Some patients may experience mild discomfort in the upper right abdomen, but this is often overlooked or misdiagnosed as other diseases, such as chronic gastritis. Therefore, once diagnosed with gallbladder cancer, it is usually already at a middle to late stage. Although the cancer embryo antigen in tumor marker tests of gallbladder cancer patients can be elevated, this is not absolute. Therefore, when discomfort in the upper right abdomen occurs, further comprehensive examinations like color ultrasound, CT, and other related tests are necessary to differentiate it.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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What should I do if gallbladder cancer causes itchy skin?

Gallbladder cancer patients may experience skin itching, as they often develop secondary obstructive jaundice. This can lead to lighter stool color, darker urine color, yellowing of the skin and mucous membranes, and generalized itching. For treatment, surgery should be performed for better therapeutic outcomes. Although medications to reduce jaundice can be used for symptomatic treatment, surgery is generally advocated, especially for early-stage gallbladder cancer patients without significant metastasis, where early surgical removal can significantly improve prognosis. Additionally, since malignant tumors are a consumptive disease, it is advisable for patients to consume a diet high in protein, such as eggs, lean meat, and fish, to supplement the proteins needed by the body and enhance the patient's immunity.