Can acute pancreatitis turn into pancreatic cancer?

Written by He Zong Quan
General Surgery
Updated on January 01, 2025
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Acute pancreatitis and pancreatic cancer are two diseases that occur in the same organ, the pancreas. However, acute pancreatitis is entirely an inflammatory change, often caused by gallstones, alcohol consumption, binge eating, and hyperlipidemia, with some cases being idiopathic. Pancreatic cancer, on the other hand, is a tumorous lesion and is a malignant tumor that generally requires surgery. Many pancreatic cancer patients are already in the advanced stages when discovered, making the surgery difficult to perform. The prognosis for patients is also completely different. After the onset of acute pancreatitis and treatment, the pancreas recovers, the inflammation subsides, and it does not affect a person's lifespan. However, if pancreatic cancer is clearly diagnosed, the lifespan oftentimes does not extend beyond a few years.

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Written by Zhou Chen
Oncology
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Pancreatic cancer is a type of cancer that arises from the pancreas.

The causes of pancreatic cancer are not yet entirely clear, but its occurrence is associated with smoking, drinking alcohol, high-fat and high-protein diets, excessive consumption of coffee, environmental pollution, and genetic factors. Recent surveys have found that the incidence of pancreatic cancer is significantly higher among diabetics than in the general population. There is also evidence suggesting a certain relationship between chronic pancreatitis and the development of pancreatic cancer, with a notably increased risk of pancreatic cancer among patients with chronic pancreatitis. Additionally, many other factors such as occupation, environment, and geography are somewhat related to the occurrence of this disease. Pancreatic cancer is not a cancer that comes from anger or emotional causes.

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Written by Yan Chun
Oncology
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What are the precursors of pancreatic cancer?

Pancreatic cancer is a malignant tumor that occurs in the digestive system clinically. Due to the hidden location of the pancreas, early symptoms of pancreatic cancer are generally not obvious. When individuals with a family history of pancreatic cancer exhibit unexplained fatigue or abdominal discomfort, or rapidly progressive jaundice symptoms in a short period, and if patients also have diseases such as diabetes, the possibility of pancreatic cancer should be considered. An abdominal CT scan, MRI, and other radiological examinations should be completed quickly. For identified pancreatic space-occupying lesions, early biopsy through puncture or direct exploratory laparotomy should be performed as soon as possible for treatment.

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Written by Shen Jiang Chao
Radiology
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Can pancreatic cancer be detected by a CT scan?

Pancreatic cancer can be detected by CT, which shows both direct and indirect signs. The direct signs of pancreatic cancer are manifested as pancreatic masses, which are mostly lobulated. On plain scans, the tumor appears isodense or slightly hypodense compared to the pancreatic parenchyma. When the tumor is large, it appears as a local protrusion, mostly located within the pancreas. In the early phase after enhancement, the tumor enhances less than the surrounding normal pancreatic tissue because pancreatic cancer is a hypovascular tumor. Indirect signs are mainly secondary changes caused by pancreatic cancer, mainly affecting the common bile duct and the main pancreatic duct, which can lead to pancreatic duct dilation, characterized by the typical double duct sign.

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Written by Liu Liang
Oncology
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How to screen for pancreatic cancer

Pancreatic cancer is a common malignant tumor of the digestive tract. Due to its high malignancy and rapid progression, it severely affects human health. So how should pancreatic cancer patients be screened? Generally, abdominal ultrasound examination is the primary screening method. Another method is the examination of tumor markers, mainly carcinoembryonic antigen (CEA) and CA19-9. CA19-9 is a tumor marker with relatively high specificity and sensitivity for the diagnosis of pancreatic cancer. Therefore, during physical examinations, we can draw blood to check these tumor markers. If there is a significant increase in CA19-9 or CEA, further examinations of the pancreas, such as ultrasound or CT of the pancreas, should be conducted to further investigate whether there is a tumor in the pancreas.

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Written by Zhou Zi Hua
Oncology
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Reasons for the low resection rate of pancreatic cancer

The resection rate for pancreatic cancer is relatively low because the pancreas is located behind the peritoneum in a deep position. In the early stages of pancreatic cancer, there are often no specific clinical symptoms. Therefore, by the time pancreatic cancer is detected in patients, it is usually already in the advanced stages. The pancreas is surrounded by blood vessels and nerves. Therefore, if it is found in the late stage, the surgical difficulty is very high, making it difficult to remove surgically, which is why the surgical resection rate for pancreatic cancer is low.