Can acute pancreatitis turn into pancreatic cancer?

Written by He Zong Quan
General Surgery
Updated on January 01, 2025
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Acute pancreatitis and pancreatic cancer are two diseases that occur in the same organ, the pancreas. However, acute pancreatitis is entirely an inflammatory change, often caused by gallstones, alcohol consumption, binge eating, and hyperlipidemia, with some cases being idiopathic. Pancreatic cancer, on the other hand, is a tumorous lesion and is a malignant tumor that generally requires surgery. Many pancreatic cancer patients are already in the advanced stages when discovered, making the surgery difficult to perform. The prognosis for patients is also completely different. After the onset of acute pancreatitis and treatment, the pancreas recovers, the inflammation subsides, and it does not affect a person's lifespan. However, if pancreatic cancer is clearly diagnosed, the lifespan oftentimes does not extend beyond a few years.

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Written by Liu Liang
Oncology
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How is pancreatic cancer diagnosed?

The most common symptoms of pancreatic cancer are pain in the upper abdomen and jaundice. During physical examination, a mass in the upper abdomen can be felt, which is a common symptom. When these symptoms appear, further abdominal ultrasound or CT scans should be performed, as these two are the most commonly used imaging methods for diagnosing pancreatic cancer. Additionally, pancreatic MRI or PET-CT can also help enhance the diagnostic accuracy for pancreatic cancer. MRCP and ERCP are also used to assess the bile ducts and to evaluate the feasibility of surgery. Blood tests for pancreatic cancer-related tumor markers, such as carcinoembryonic antigen (CEA) and CA19-9, are commonly performed, with CA19-9 being particularly sensitive and specific for the diagnosis of pancreatic cancer.

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Written by Cui Fang Bo
Oncology
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Can late-stage pancreatic cancer cause vomiting blood?

For patients with advanced pancreatic cancer, there is a possibility of vomiting blood. Vomiting blood is one of the manifestations of upper gastrointestinal bleeding. In some cases, patients with pancreatic cancer may experience upper gastrointestinal bleeding: 1. Stress ulcers, in patients with advanced tumors, sometimes occur due to extreme physical debilitation, leading to stress ulcers. These ulcers cause localized erosion of the gastric mucosa, eventually leading to bleeding; 2. Thrombocytopenia, for patients with advanced pancreatic cancer, most need to undergo systemic chemotherapy. Chemotherapy can suppress the function of the bone marrow, leading to a reduction in peripheral white blood cells and platelets. When platelets decrease to a certain level, the body's clotting functions may be impaired, concurrently leading to upper gastrointestinal bleeding.

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Written by Yan Chun
Oncology
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What causes pancreatic cancer?

Pancreatic cancer is a malignant tumor of the digestive system whose incidence has gradually increased in recent years. The exact cause of pancreatic cancer is still unclear, but there are several factors that can increase the incidence of pancreatic cancer: 1. Age factor: Statistical data shows that the incidence of pancreatic cancer increases with age. 2. Dietary factors: Clinical research data confirms that some poor eating habits, such as consuming too much high-fat and animal protein, can significantly increase the incidence of pancreatic cancer. 3. Unhealthy lifestyle habits: People who smoke heavily and drink alcohol over a long period have a significantly higher incidence of pancreatic cancer compared to the general population. 4. Other benign pancreatic diseases, such as diabetes: Statistical data indicates that among diabetic patients, especially those with Type 2 diabetes, there is a slight increase in the incidence of pancreatic cancer.

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Written by Wu Hai Wu
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How to deal with lower limb edema in advanced pancreatic cancer?

In late-stage pancreatic cancer, bilateral lower extremity edema should be considered possibly due to hypoalbuminemia, which leads to edema in both legs. It is also possible that cancer emboli in late-stage pancreatic cancer block the venous system, causing impaired venous return and resulting in bilateral lower extremity edema. To determine the specific cause, it is necessary to complete ultrasonographic examinations of the blood vessels in the lower limbs, as well as liver function tests, complete blood count, and others. After clarifying the diagnosis, appropriate treatment measures should be taken based on the different causes. For example, if the edema is caused by hypoalbuminemia, active supplementation with albumin and diuretics, among other treatments, is required. (Note: The use of medications should be carried out under the guidance of a professional doctor.)

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Reasons for the low resection rate of pancreatic cancer

The resection rate for pancreatic cancer is relatively low because the pancreas is located behind the peritoneum in a deep position. In the early stages of pancreatic cancer, there are often no specific clinical symptoms. Therefore, by the time pancreatic cancer is detected in patients, it is usually already in the advanced stages. The pancreas is surrounded by blood vessels and nerves. Therefore, if it is found in the late stage, the surgical difficulty is very high, making it difficult to remove surgically, which is why the surgical resection rate for pancreatic cancer is low.